Leukemia

There are multiple supplements and compounds with good evidence of reducing risks and improving quality of life in leukemia patient studies. Often by protecting and boosting immune system health and lowering inflammatory responses that tend to fuel cancer progression.

The two most used and well proven herbal extracts, danshen and astragalus, are shown to have strong impacts when added to oncology treatments, mainly chemotherapy. Data from both Tiawan national patient records and collective study across several trials report much lower progression risks. Other research reports low immune system related inflammatory responses significantly improve outcomes, Re-balancing immune system inflammation levels, the neutrophil-to-lymphocyte ratio and improving low platelet count both reduce risks quite substantially. A natural immune modulator, astragalus has evidence of supporting immune system balance both before and during oncology treatments. Also continuing to develop in oncology practice are beta glucans, in this case derived from yeast. Stimulation and restoration of immune system responses, again, supports significanly improved treatment results. Like astragalus and danshen, users of beta glucans frequently experience lower side effects from treatment.

For leukemia patients treated with tyrosine kinase inhibitors such as ibrutinib, a 2025 large analysis across nearly 1500 cases showed that stain use results in a large risk reduction both for progression and all causes. Its to be proven if this effect would be seen in the other 71% of patients who were not on statins, or a sub group of those. But a remarkable effect none the less. Statins users, especially those who respond with lowered cholesterol, are often reported with improved outcomes in cancer therapy and that includes leukemia. Importantly, at least one study showed even greater benefits in patients taking low dose aspirin alongside statins. Atorvastatin is the most researched prescription drug while widely proven red yeast rice supplements are the source of lovastatin, its cousin.

Another compound gaining a large body of both observational and clinical data is vitamin D3, there is overwhelming evidence of the poor prognosis in deficient patients, and increasing progress in benefits of supplementation. Higher dose vitamin D3 is gaining attention too, particularly for higher BMI patients.

Also from large scale analysis of patient records, use of H1 class antihistamine desloratadine reduced risks for progression in leukemia. Similar data also confirms superior response rates during immunotherapy for melanoma and lung cancer treatment, which researchers suggest are applicable in other disease including leukemia.

Treatment outcomes in blood cancers including leukemia can be heavily influenced by gut microbiome. Having is high diversity of gut bacteria is reported to improve response and reduce overall risks. Crucially, therapy failure is linked to poor gut microbiota and in particular deficient or absence of blautia and akkermansia bacteria. Some necessary oncology treatments may reduce levels of these bacteria as do antibiotics. Also related to diet, there is some fascinating research in fasting mimicking diets in early stage chronic lymphocytic leukemia (see Lifestyle)

Successful treatment relies strongly on how quickly new white blood cells can be produced. The Nicotinamide Riboside variant of vitamin B3 has been extensively studied in anti-aging science for its ability to increase cellular mitochondrial health. Now, there are is remarkable pre-clinical evidence that this vitamin can substantially increase stem cell activity that drives production of new white blood cells. Related, nicotinamide B3 has reached phase II for reducing incidence of melanoma in leukemia patients.

Dysfunctional iron metabolism is a signature of blood cancers. Elevated levels of enzyme like protein ferritin are seen in tumors and in circulation, promoting progression. Conversely anemia is common in patients and increases risks. Lactoferrin has very potent iron binding capacity, and increases iron balance, homeostasis. Potentially even in relation to iron overload from transfusions. Also metal related, new clinical studies show increased circlating copper bought on by cancer activity is s large risk factor, and many patients were deficient in zinc. Citrus Pectin has evidence of removing heavy metals over a period of weeks, and has its own anti-cancer activity.

Systemic acute type inflammation is associated with most cancers, and often measured with c-reactive protein. Supplements including curcumin, garlic and an anti-inflammatory functional food regime are all evidence based interventions.

The so called Th1/Th2 immune system balance is strongly linked to the progression in leukemia and to treatment resistance. Molecular iodine solutions are emerging in this area in breast cancer management, seen boosting Th1 anti tumor activity and helping suppress over active Th2 used in resistance. This has improved results in surgery plus chemotherapy and may support increased responses during immunotherapy (see Supplement Library). For immunotherapy the presence of high sodium levels is now identfied as a key marker for success in other cancers. Also in other cancers, AM treatment programs are substantially more effective that PM/evening sessions

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Danshen evidence from patient records is compelling in both cancer and vascular health

Aggregated study across the 3 highest quality chinese clinical trials
Danshen impacts here are consistently large, reducing progression risk by around 75%
Confimatory evidence in national patient records in Tiawan shows 59% risk reduction

This paper was a systematic review of 13 high-quality RCTs [research clinical trials], including 1045 participants, to determine the efficacy and safety of the Danshen formulae for cancer treatment. Our study showed that the Danshen formulae provide statistically significant benefits in improving RR [complete + partial response, leukemia studies showed the highest response levels] (OR 2.38 ), 1-year survival (OR 1.70), 3-year survival (OR 2.78), and 5-year survival rate (OR 8.45)Current evidence suggests that Danshen formulae can be used as an effective adjuvant for treat cancer.

Akkermansia continues to emerge in oncology as one key bacteria strain especially with immunotherapy

Low or no akkermansia and blautia gut bacteria reported with treatment failure
Necessary oncology treatments an antibiotics seen to reduce levels
Diversity of gut microbiota has extensive research showing improved outcomes

Lower microbial gene richness, a lower abundance of the genus Blautia, and a lower abundance of Akkermansia muciniphila, early post-aHSCT was observed in those who developed aGVHD. Myeloablative conditioning was associated with aGVHD along with a reduction in gene richness and abundance of Blautia and A.muciniphila. These results confirm low diversity and Blautia being associated with aGVHD. Crucially, we add that pretransplant conditioning [chemo/radiotherapy] is associated with changes in gut microbiota. Investigations are warranted to determine the interplay of gut microbiota and conditi...

Red Yeast Rice or a prescription statin have multiple impacts including lower all-cause risks

Users of statins during treatment show strongly improved outcomes
Strikingly large risk reduction level of 61%, progression free risk reduced 27%
Chronic lymphocytic leukemia (CLL) treated with TKI ibrutinib

This study provides valuable insights into the associations of baseline statin use with survival and adverse event outcomes in patients with CLL/SLL initiating contemporary treatment regimens. The findings revealed a statistically significant association between statin utilization and improved OS, PFS, and cancer-specific survival. The latter suggests a potential disease-modifying effect of statins in this patient population. No significant associations were observed between statin use and the occurrence of grade ≥3 adverse events. Notably, statin use emerged as a consistent positive prog...

Vitamin D3 and its immune system health actions are key, higher doses being trialed in oncology

Supplementation from diagnosis doubles Time To First Treatment for patients under 65
In related studies, insufficent levels of D3 are clearly linked to poor outcomes
New interventional trial reports risk reduction around a half in post treatment outcomes

We found that vitamin D supplement was statistically significant for longer TTFT in the young cohort (age ≤65) and was associated with a longer TFS for all ages (P = .004). Among non–vitamin-D users, the median TFS was found to be 84 months, whereas among vitamin D supplement users the median TFS extended to 169 months. In conclusion, our long-term retrospective study demonstrates that the administration of vitamin D to patients with CLL in a watch-and-wait active surveillance is significantly associated with a longer TFS (in any age) and a longer TTFT among young patients (...

Astragalus actions include protecting and balancing immune responses often with clear effects reported

Tiawan national patient records shows a 59% average risk reduction with herbal medicines
Lower immune system inflammatory response is closely linked with improved outcomes
Astragalus has evidence for reducing this inflammation seen in neutrophil-to-lymphocyte ratios

It is a reasonable assumption that a portion of AML patients seek complementary forms of therapies following their diagnosis. Although this study cannot replace a controlled clinical trial or prove a causal relation, it strongly suggests that adjunctive CHM [chinese herbal medicine] therapy may benefit AML patients of all ages, including those with poor prognosis. We are unable to infer whether this is a direct result of the CHM consumed, a synergistic effect with standard agents, or even just a result of the former reducing the adverse effect of the latter and consequently leading to more ...

Beta glucans protect and balance immune system activity improving outcomes

Pharma grade beta glucan phase II trial with promising rates of complete remission
Almost halves the percentage of patients requiring re-treatment at 3 years
Recent trials in lymphomas show very similar positive effects for patients

This phase I study shows that PGG beta glucan (yeast derived odetiglucan) can be safely combined with alemtuzumab and rituximab for the early therapy of patients with high risk CLL. The limited data set suggests that this combination is effective at achieving a high rate of complete responses. However, because of the limited accrual to the phase II component of the study, these data remain preliminary. PGG beta glucan was generally well tolerated and the 3 grade 3-4 toxicities

Vitamin B3 in several forms shows protective effects in cancers

Vitamin B3 riboside variant accelerates activity of hematopoietic stem cells
Large protective effect in mouse model gave dramatically higher survival
B3 is widely available and has supporting evidence in other cancers

NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation….Our work demonstrates for the first time a positive effect of NAD⁺-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision, and unveiling the potential of NR to improve recovery of patients suffering from hematological failure including post...

Berberine evidence in metabolic health may help counter cancers use of lipids and sugars to grow

Elevated levels of TIGAR sugar metabolism strongly affect prognosis
Patients with relatively low levels saw over 50% increased survival rates
Berberine research shows it strongly binds TIGAR in its glucose clearing actions

In summary, our study showed that high TIGAR expression was associated with poor survival and a high incidence of relapse in adult patients with CN-AML, even after adjustment for known clinical and common molecular risk factors. Moreover, sustained TIGAR activation, uncoupled from p53, may support AML cell growth and survival. TIGAR in cooperation with glycolysis had a strong anti-apoptotic effect in AML cells. Therefore, the combination of TIGAR inhibitors with anti-glycolytic agents may be powerful novel therapies for the future clinical use in AML patients.

Lactoferrin increases iron balance and reduces anemia rates, countering cancers use of iron

Lower levels of ferritin reduce risk levels and improve treatment responses
The meta-analysis shows about half the risk for progression with low ferritin
Iron deficiency or anemia are very common and also significant risk factors

Serum ferritin (SF), a test that measures body’s iron stores and inflammation, has been established as a worthwhile prognostic impact indicator for myelodysplastic syndromes, including acute myeloid leukemia (AML)…four out of five studies compared survival rates for Progression Free Survival, Disease Free Survival (DFS), Recurrence Free Survival (RFS), and Event-Free Survival (EFS). Despite the significant heterogeneity, a pooled HR still showed a poorer prognostic association between high SF and AML (HR: 1.88)…Elevated SF levels have been associated with adverse effects o...

Citrus Pectin removes heavy metals such as copper and has its own anti-cancer mechanisms

Study of the impact of blood levels of circulating copper and zinc
Relatively lower copper levels are reported as a 2.5X lowered risk
Most patients had deficient zinc, and Copper/Zinc ratio has similar findings

SCL [copper] and SCZR [copper/zinc] were positively related to the blast percentage of bone marrow and C-reactive protein… were significantly associated with worse overall survival and disease-free survival. Meanwhile, patients with higher SCL had worse CTCAE levels [adverse events], and patients with higher SCZR showed less complete remission during the first course of induction chemotherapy. Moreover, higher SCZR was positively associated with ELN risk stratification [genetic factors], and was negatively associated with hemoglobin level and prognostic nutritional index (PNI)

Curcumin has evidence for reducing levels of systemic inflammation used by cancers

Sustained low inflammation levels give large risk reductions
An overall risk reduction of two thirds is reported here
Importantly, an 80% risk reduction for developing a second cancer

Unlike lymphomas, especially the more aggressive subtypes, where CRP is markedly increased and linked to poor prognostic parameters elevated CRP in CLL appears to be less related to the malignancy itself and more obviously associated with other findings, such as the risk of developing second cancers…Taken together, elevated CRP is an independent predictive factor for decreased OS and an increased risk of developing a second solid malignancy in patients with CLL. We propose that increased CRP in patients with CLL is a potential marker for early cancer detection and may well justify a m...

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Pathfinder Element	Risk Reduction Factor	Anti-Metastatic	Reduces Side Effects	Research Study
Astragalus	>50%	Yes	Yes	Link
Danshen	>50%	Yes	Yes	Link
Red yeast rice/ statin	>50%	Probably	Maybe	Link
Vitamin D3	26 - 50%	Yes	Maybe	Link
Beta Glucan	26 - 50%	Yes	Yes	Link
Citrus Pectin	Indirect - High	Probably	Yes	Link
Gut microbiome / Akkermansia	Indirect - High	Probably	Yes	Link
Lactoferrin	Indirect - High	Probably	Yes	Link
Vitamin B3	Indirect - High	Maybe		Link
Berberine	Indirect - Moderate	Maybe	Maybe	Link
Curcumin	Indirect - Moderate	Maybe	Maybe	Link

Plan Item	Cancers	Background Details	Trial Doses Under Supervision	References
Antihistamines	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Pancreatic, Melanoma, Lymphoma, Esophageal, Bladder	Research indicates desloratadine for localized cancers or loratadine for metastatic. There are examples of ebastine or other alternatives in certain cases. Growing research evidence indicates improved oncology responses. Taken between meals. Low histamine before and during treatment is beneficial.	Active use in clinical trials is still in early phase, follow the dose recommendation for instance 5mg daily unless under medical supervision where higher 10mg doses are frequent
Aspirin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Melanoma, Myeloma, Head and Neck, Bladder, Gallbladder, Non Melanoma Skin, Gastric	Use of low dose 75 or 81mg "baby" aspirin is reported to benefit many cancer types across an average study group, and even all cause mortality. There are some indications of specific "responders" for instance those with existing inflammatory conditions or certain gene expressions. With food.	In a colorectal cancer trial responders were tied to the expression of particular genes (PI3KA). Doses were 160mg	LINK
Astragalus	Breast, TNBC, Lung, Colorectal, Liver, Gastric, Cervical, Endometrial, Pancreatic, Prostate, Kidney, Ovarian, Glioblastoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Bladder, Gallbladder, Thyroid	A typical astraglaus membranaceus supplement may have 50mg of astragaloside IV the main active compound. Its possible with meals can reduce any stomach upset. Use of a standard dose to help immune system balance before treatment.	Here, Astragalus is added to standard oncology in lung cancer Doses are 2-3 tablets of 250mg AMe (Solgar, NJ, USA) minimum for 6 months in this example	LINK
Beta Glucans	TNBC, Lung, Liver, Gastric, Cervical, Pancreatic, Melanoma, Non Hodgkin, Lymphoma, Leukemia	There are many options for mushroom or yeast 1,3/1,6 glucan and branded products include California Gold Immune Defense/Wellmune, AHCC, Biogen/ Yestimun, ImmiFlex, IP6 and many more. A pharma grade product, odetiglucan, is continuing in trials. Take on an empty stomach. Use a standard dose to help balance the immune system before starting treatments.	AHCC is used at 3x1g per day over several months during treatment. Beta glucans are used at 1-2g per day and higher.	LINK
Danshen	Breast, Prostate, Lung, Colorectal, Liver, Leukemia, Myeloma, Bladder	The most common chinese herbal medicine in oncology, also known as red sage. Premium brands such as MCS may recommend 1g twice daily as an ongoing dose. Its possible with meals can reduce any stomach upset. Start a standard dose a couple of weeks before treatment to help balance the immune system.	3 x1g daily between meals , over at least 90 days ideally longer to get maximum benefits according to reported patient outcomes, though even shorter dose period reduced risk	LINK
Green Coffee Extract	Glioblastoma	Supplements vary in terms of their chlorogenic acid content, it can be up to 50%. Quality brand might specify this level under their recommended intake. High dose commercial brands may be over 1000mg total, take before meals.	Analysis across trials reports metabolic health benefits start are higher at >500mg or daily. High chlorogenic acid content supplements eg Svetol have been trialed safely for 12 weeks at 200mg x 5 daily dose. As always, be aware of possible drug interactions	LINK
Red Yeast Rice Or statin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Endometrial, Melanoma, Leukemia, Myeloma, Head and Neck, Esophageal	Red yeast rice is equivalent to lovastatin. Doses are essentially on the products, and there are many premium brands with guaranteed level of monokolin k around 3mg. A common theme is findings is those with improved cholesterol are "responders". With meals. Start cholesterol and inflammation reducing statins early.	Trial data is often case studies with multiple statins where lovastatin has average effects. Often atorvastatin and sometimes simvastatin come out on top. Research ususally reports intermediate doses ( 10-20mg) are effective but there are examples indicating higher doses under supervision.	LINK
Turkey Tail	Lung, Colorectal, Kidney, Liver, Gastric	A typical premium supplement such as MCS recommend 700mg twice daily with food. Mushroom based glucans can help balance immune response so start them before your treatment.	Pharma grade turkey tail, e.g PSP/ PSK/ Krestin is typically used at 3x 1g daily during oncology, up to 36 months and more. Trials in breast cancer have also used 3,6 and 9g daily regimes in 6 week periods	LINK
Vitamin D3	Breast, TNBC, Prostate, Lung, Colorectal, Gastric, Ovarian, Pancreatic, Glioblastoma, Melanoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Esophageal, Bladder	High dose commercial formulae can be 10,000IU. Which might be achieved by as little as 10 to 20 minutes in sunshine. Vitamin K2 is advised with D3. Take with some food containing fat. Its important to ramp these up before oncology treatments, and sustain the higher levels over time. Add magnesium for best absorption and metabolism.	The VITAL trial used 2000IU and discussed the potential of higher doses to increase responders especially higher BMI/ body weight. Whilst in prostate cancer there are trials demonstrating at least 10,000IU is required to see activity reducing PSA levels	LINK
Melatonin	Breast, TNBC, Prostate, Lung, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Glioblastoma	Commonly used in 10 to 40mg daily range no reported side effects, typically an hour before sleep.	Moderate and high dose trials report no significant side effects even at 1000mg daily	LINK
Citrus Pectin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Non Hodgkin, Leukemia, Myeloma, Head and Neck, Esophageal, Bladder, Gallbladder, Thyroid, Gastric	Trials use a recommended dose up to 5g x3 daily and no significant side effects. Taken 30 minutes before or 90 minutes after food. Ideally, start PectaClear or similar products at least 4 week before treatment to reduce heavy metals. But sustain zinc with supplementation	Even in children age 5 to 12 the daily regime 3 x 5g was safe and effective for heavy metal chelation	LINK
Soy Isoflavones	Breast, Prostate, TNBC	Often dietary sources, tofu and soy based and no evidence of side effects. Supplements generally with food.	In a clinical trial setting up to 900mg with no issues	LINK
Fermented Wheatgerm	Prostate, Colorectal, Melanoma	Trials are with Avemar brand products with no significant safety concerns reported	Typical dose regimes may be aroung 9g daily over longer time periods for instance 12 months	LINK
Iodine	Breast, TNBC	General usage around 1000mcg or 1mg generally with food	Successful pilot studies in breast cancer use 5mg molecular Iodine daily for the duration of therapy	LINK
Lactoferrin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Endometrial, Pancreatic, Glioblastoma, Melanoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Bladder, Esophageal, Gallbladder, Thyroid	200mg typical use daily , eg 10ml liposomal formula ideally 30 minutes before meals or 2 hours after. No side effects of note. Start this immediately to achieve and maintain healthy iron absorption, avoid deficiencies and reduce cancer related ferritin levels.	During oncology doses of up to 3g to 9g daily, even higher, have been used with significant side effects	LINK
Selenium	Breast, Lung, Kidney, Ovarian, Cervical, Endometrial, Pancreatic, Melanoma, Head and Neck	Supplements are 200ug doses and similar amounts from about 3 brazil nuts. Start buildin gup your levels immediately and keep them high during oncology. Selenium toxicity is a consideration for high doses over time, so seek medical advice. Ideally taken with meals.	This trial used 2500 to 4000ug 2x daily for 14 days then once daily in kidney cancer with no dose limiting toxicity	LINK
Vitamin B3	Liver, Gastric, Glioblastoma, Non Hodgkin, Lymphoma, Leukemia, Non Melanoma Skin	Typically 500mg for nicotinamide (niacinamide) form of B3 taken ideally with meals	Do not differ from standard doses, here 500mg twice daily related to skin cancer	LINK
Akkermansia	Breast, TNBC, Prostate, Lung, Kidney, Liver, Ovarian, Cervical, Pancreatic, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Gastric	Commercial products may be at 10B CFU typically 30 minutes before or 2 hours after food. Ramp up levels with diet and moderate supplementation before treatments, especially immunotherapy.	Under development. Results in oncology indicate this is one of many helpful guy bacteria. careful consideration and particularly following use of antibiotics. Diversity is crucial.	LINK
Berberine	Kidney, Liver, Cervical, Pancreatic, Non Hodgkin, Leukemia, Myeloma, Head and Neck, Esophageal, Gallbladder, Thyroid, Non Melanoma Skin, Melanoma, Bladder	A natural anti-diabetic used frequently at 400mg daily and above, shortly before meals	In metabolic health trials frequentlu use up to 500mg at 3 times daily .	LINK
Curcumin	Colorectal, Liver, Non Hodgkin, Myeloma, Bladder, Gallbladder, Non Melanoma Skin, TNBC, Breast, Prostate, Lung, Kidney, Gastric, Ovarian, Cervical, Endometrial, Glioblastoma, Melanoma, Lymphoma, Leukemia, Head and Neck, Thyroid	Doses from 500mg to 2000mg frequently seen. Piperine fron black pepper improves absorption, highly bioavailable formulae are available. Ideally with a meal containing fat.	Higher doses in trials are frequently 2 of 4 g daily (+40 mg piperine) during oncology for instance here at 3 periods of 30 days	LINK
Quercetin	Glioblastoma, Myeloma	Can be found in a healty diet. Supplements often 500 or 1000mg and can be taken with tocotrienols for enhanced absorption, a form of vitamin E . Some evidence that Quercetin should be pulsed on/off.	Clincial trials have safely used up to 5g daily in adults, and 1 to 4g for rare forms of paediatric anemia	LINK
Urolithin A	Prostate, Lung, Colorectal, Kidney, Gastric, Glioblastoma, Melanoma, Myeloma, Gallbladder, Head and Neck	Typical commercial brands run at 500mg once or twice daily, with or without food, some brands suggest with meals	Trials eg in anti-aging science use the same dose range	LINK
Oat and Egg Functional Food	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Cervical, Pancreatic, Glioblastoma, Melanoma, Head and Neck, Gallbladder	Follow supplier guidance on dosage and use. https://shop.lantmannenfunctionalfoods.com/? Lowering tumor fluid pressure helps treatments work, start these before your treatment if possible. Use egg based salovum for short term "pulse" during therapy and oat products for sustained use over longer time periods	This trial in glioblastoma used 16g egg based Salovum four times daily. It discusses lowering that regime in follow on trials.	LINK
Coffee	Breast, Prostate, Colorectal, Liver, Non Melanoma Skin	Most dietary studies use standard 8oz servings as a guide. In many cases the findings are that benfits increase with intake. But in some cases such as prostate cancer there are important details in the PATHFINDER	No, but chlorogenic acid and, separately, green coffee extracts are used at 400mg and up to 2000mg
Flax	TNBC, Ovarian	Crushed flaxseed alone or in foods around 1/4 cup daily	Doses up to 50g daily in clinical trials for various diseases. Here a fairly typical 30g regime in inflammatory liver diseases	LINK
Propolis	Breast	Typical supplements range from 400 to 1000mg	Here 400mg x3 daily help recovery from radiotherapy	LINK
Walnuts	Prostate, Colorectal, Melanoma, Head and Neck	Dietary food item shown even at low useage to be helpful even at a few oz per week	Here, 2oz (56g) daily showed measurable activity in breast cancer	LINK
Mushroom	Prostate	Both dietary sources and many commercial supplements normally taken with food	In this example some patients saw responses between 8 and 14g daily of button mushroom extract	LINK
Zinc	Kidney, Ovarian, Cervical, Endometrial, Head and Neck, Non Melanoma Skin	Commercial supplements vary considerably . Moderate 20mg range generally advised	No
Intravenous HIgh Dose Vitamin C	Pancreatic, Glioblastoma	Commercial supplements vary. A moderate range around 20mg with food is generally accepted as safe.	Same as general guidance
Alpha Ketoglutarate	Melanoma, Kidney, TNBC, Non Hodgkin, Lymphoma	Typical usage is 1000mg daily with or without food, safety is good. Its especially important to ramp up and sustain your levels for maximum immunotherapy responses.	Larger doses of several grams have been safely used in various trials including here in bone disease at 6g daily	LINK
Horse Chestnut (Escin)	Thyroid	Common 300 to 600mg supplements contain 50 to 120mg of active compound, escin taken with food	Escin up to 150mg daily in vascular health. In oncology 0.6 mg/kg/day for 9 days, intravenous injection has been used, high absorption premium supplement would reacj this level	LINK

About a third of cases are Chronic Lymphocytic Leukemia (CLL) and start with an active suveillance phase for many. Other more rapidly progressing leukemias can be treated with chemotherapy of a growing range of targeted drugs or immunotherapies depending on subtypes and details of diagnosis. There is some use of stem cell therapy.

Your PATHFINDER brings together research that may help slow down early phase progression in CLL considerably. And, with advancing disease of any type, the Pathfinder helps maximize the effects of chemotherapy, targeted drug treatments or immunotherapy. The IMPACTS tab summarizes these and can lead to Many more Good days by helping these treatments work, reducing your risk for progression and by easing treatment side effects. You can continue to look for ways to increase the results and reduce possible toxicities;

Be sure to fully read and absorb the PATHFINDER and its Impacts summary
If you have metastatic sites, so called extramedullary leukemia, take a look into the corresponding Pathfinder for those too for inspiration.
Use the Supplement Library Index and filter on “Chemotherapy” and “Targeted drugs” etc for ideas.
The Foods Library can complement your plan, including anti-metastatic strategies and metabolic health
In the Lifestyle section gathers fascinating evidence for diets and exercise
The PLANS section may have information from what others are doing and have learned

Leukemia

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