Luteolin can be derived from many dietary sources but is especially high in radicchio. A supplement is an easy option though. Recently, low 50mg doses over 6 months has been shown to suppress activity of so called androgen receptors in low grade, early stage prostate cancer. In a pilot study half or patients on active surveillance responded, even at low levels, and one patient experienced complete disappearance of at least one cancerous lesion. The anti- cancer actions are similar in nature to those of enzalutamide the leading androgen receptor drug therapy. A significant number of breast cancers are so called androgen receptor positive, and some respond to the same drugs used in prostate cancer. a clear signal that luteolin should be explored there.

There is also new evidence that the actions of luteolin may directly reduce progression rate of gastric cancer through actions on so called Notch1 signaling. Researchers examined the link to progression and spread in gastric cancer driven by dysfuntional levels of Nothch1 signaling. Approximately a forty percent risk reduction is found in patients maintaining lower Notch1 expression, due to decreased metastatic activity. They go on to show particularly large reductions in Notch1 from actions of luteolin in pre-clinical trials.

Dietary intake of luteolin has been seen suppressing insulin resistance and systemic inflammatory markers such as c-reactive protein. Lowering CRP is invariably linked to lowering risks. New research in early stage prostate cancer shows measurable anti-cancer activity at 50mg, the pilot study reporting a clinical benefit in patients with no adverse events at 50mg (highlight 1). Progression rates in liver, colorectal, breast cancers and more are also assocated to insulin resistance and more with inflammation including kidney and lung cancer. There are population studies in type 2 diabetes showing metabolic and cardiac health benefits even in modest dietary amounts, so far no application studies directly in cancer where effects are more likely to be seen in combining multiple active compounds.

Together with Chlorogenic acid (see Green Coffee Extract) , a commerical brand Altilix(R) has shown good evidence of cholesterol and glucose reduction for heart and liver health. Artichoke extracts are also high in luteolin, and can encourage crucial bacteria in the microbiome. Meta-analyses partly confirms lowered cancer incidence with high flavonoid diets. There is limited clinical evidence to assess luteolin specific actions in systemic health. The few studies available do confirm significant anti-inflammatory actions associated with flavanoids overall (see References).