GYMNEMA SYLVESTRE

Gymnema Sylvestre has good clincial evidence for improving both glucose and cholesterol related metabolic health markers, which can be associated to increased cancer progression.

It is a natural anti-diabetic with somewhat different actions to berberine (highlight 3), and might be used as a complement for sustaining low blood glucose levels. And has shown the ability to amplify the positive outcomes of dietary regimes for weight loss. Over use can challenge liver function, as always seek medical advice before using supplements like gymnema.

TYPICAL ABSORPTION LEVELS

10 – 20%

EXAMPLES OF IMPROVED OUTCOMES

PRE-DIAGNOSIS OR PREVENTION

Highlighted Studies

G. sylvestre administration in patients with IGT (impaired glucose tolerance) decreased 2-h OGTT and A1C, increasing insulin sensitivity. There were also improvements in anthropometric measures and the lipid profile..The administration of G. sylvestre improved glucose metabolism in patients with IGT by significantly decreasing 2-h PG and A1C and increasing insulin sensitivity. Moreover, it promoted a decrease in BWt, BMI, and LDL-C.

..the treated group experienced a greater improvement, especially concerning the variation from the baseline of HOMA index, triglycerides, BMI, body weight, and waist circumference. These findings support the supplementation with myo-inositol and d-chiro-inositol in the 40:1 ratio, α-lactalbumin [contains cysteine, not recommended for cancer], and Gymnema sylvestre as a therapeutical strategy to potentiate the beneficial effects induced v...

.A comparative analysis of the final measurements revealed a lower gene expression of Ap and Vis in patients treated with BBR [berberine] than in those treated with GS …In patients with obesity, BBR has a better effect on body composition, blood pressure, and the gene expression of adipokines related to metabolic risk, while GS has a better effect on fasting glucose and adipokines related to insulin resistance, with minimal side effects.

The findings of this study may support the use of dietary supplements based on myo-Ins and d-chiro-Ins [Inositol], α-LA [lactobacillus pre-biotics], Gymnema sylvestre, and zinc as an adjuvant therapy for improving lipid disorders in patients with T2DM [type 2 diabetes] already undergoing hypoglycemic treatments.

TABLE OF REFERENCES

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URL	Rating	Highlight	Highlight 2
https://magistralbr.caldic.com/storage/product-files/2110652264.pdf	2	The administration of G. sylvestre improved glucose metabolism in patients with IGT by significantly decreasing 2-h PG and A1C and increasing insulin sensitivity. More- over, it promoted a decrease in BWt, BMI, and LDL-C. It is important to note that this is the first study aimed at deter- mining the effect of G. sylvestre in patients with IGT.	After the administration of G. sylvestre, a significant de- crease was observed in 2-h PG, A1C, LDL-C, BWt, and BMI, as well as an increase in the Matsuda index. There were no differences in the placebo group. There were no intergroup differences in all variables at the end of the in- tervention (Table 1). In the G. sylvestre group, the A1C values considered for the diagnosis of patients with prediabetes were normalized in 46.7%
https://pmc.ncbi.nlm.nih.gov/articles/PMC10385591/	2	After a 6-month treatment, all parameters improved in both groups. Nevertheless, the treated group experienced a greater improvement, especially concerning the variation from the baseline of HOMA index, triglycerides, BMI, body weight, and waist circumference. These findings support the supplementation with myo-inositol and d-chiro-inositol in the 40:1 ratio, α-lactalbumin, and Gymnema sylvestre as a therapeutical strategy to potentiate the beneficial effects induced via dietary programs in dysmetabolic patients.	Gymnema sylvestre allows reducing the sweet perception and intensity. Many studies demonstrated that this wild herb significantly reduces fasting blood glucose and glycated hemoglobin in different patients with metabolic disorders [41]. Moreover, when orally administered to rats with hyperlipidemia, Gymnema sylvestre reduces total cholesterol, LDL, and triglycerides. [42]. Considering its role in the regulation of carbohydrate and lipid metabolism, it was quite predictable that the combination with inositols would strengthen their positive effects, and, to the best of our knowledge, this is the first study demonstrating this synergy.
https://www.mdpi.com/2072-6643/16/14/2284	2	We conclude that BBR is more effective than GS in the treatment of patients with obesity in terms of body composition parameters, blood pressure, and related adipokines (Vis, Ap, and Ome), while GS may have a better effect on reducing fasting glucose and its related adipokine Res. Based on these results, we propose that GS and BBR can complement the management of patients with obesity and T2DM with minimal side effects.	GS reduced the gene expression of Res, while BBR lowered the gene expression of Vis and Ap and enhanced Ome (Figure 1). These results can be explained by GS’s effect on glucose metabolism parameters, while BBR enhances lipid metabolism and fatty acid oxidation, and reduces adipogenesis and insulin resistance in adipocytes, thereby alleviating obesity and inflammation [55,56,57,58]. Both effects lead to a reduction in the proinflammatory and pro-oxidant state of adipose tissue, lowering the production of harmful adipokines
https://www.sciencedirect.com/science/article/pii/S2097382924000350	1.5	G. lactiferum herbal tea supplementation with proper monitoring arrangement of other parameters, had long-lasting significant reductions in HbA1c. Further to this it controlled elevated blood pressure in hypertension patients, total, LDL Cholesterol and Triglycerides in the third month and over the post-intervention period with no significant reduction in HDL Cholesterol level.	In the subgroup analysis that evaluated the participants with poorly controlled glycemia (HbA1c ≥8), which accounted for over 52 % of all participants, a clinically significant reduction in HbA1c was observed in the treatment and control arms...significant reductions in blood pressure and lipid profile were also noted at the end of the third month
https://www.mdpi.com/2077-0383/12/24/7650	1.5	This randomized clinical trial highlighted for the first time the benefits of the reported combined natural molecules on the lipid profiles of patients with T2DM [type 2 diabetes]. In the treatment of T2DM, it is vitally important to not only control hyperglycemia, but also to monitor the lipid profile to prevent or avoid additional health complications. The findings of this study may support the use of dietary supplements based on myo-Ins and d-chiro-Ins [Inositol], α-LA [pre-biotic lacto-bacillus] , Gymnema sylvestre, and zinc as an adjuvant therapy for improving lipid disorders in patients with T2DM already undergoing hypoglycemic treatments.	Our study represents the first randomized clinical trial highlighting that a dietary supplement consisting of inositols, α-LA, Gymnema sylvestre and zinc may be a safe and effective strategy for improving the lipid profiles of subjects with T2DM. Even though the IIT analysis displayed improvements within the study group, a subgroup analysis revealed improved levels of lipid markers in the study group compared with the placebo. Moreover, the supplementation group demonstrated greater weight loss compared with the placebo.
https://www.mdpi.com/2072-6643/16/15/2459	2	Compared to the placebo, FBG and glycated haemoglobin (HbA1c) [markers of blood glucose level] were significantly reduced in group 1 subjects. In contrast, at the doses of one and two tablet(s)/day, the FS exerted no effect on the other parameters examined. We conclude that in subjects with slightly impaired FBG, ingestion of a FS based on Z. mays and G. sylvestre extracts, zinc, and chromium over 3 months lowers FBG and modulates glucose homeostasis by improving glucose metabolism. These beneficial effects occur in the absence of biochemical evidence of kidney and liver toxicity.	The results of this study demonstrate that a food supplement containing zinc, chromium, and extracts from Z. mays and G. sylvestre, when given for three months to subjects with mildly impaired fasting blood glucose concentrations, regulates glucose homeostasis by enhancing glucose metabolism. Larger-scale research is needed to support, in the long-term, the results of the current study and provide further knowledge of the use of this food supplement.
https://www.liebertpub.com/doi/10.1089/jmf.2017.0001	2	After G. sylvestre administration, significant decreases in BWt (81.3 ± 10.6 kg vs. 77.9 ± 8.4 kg, P = .02), BMI (31.2 ± 2.5 kg/m2 vs. 30.4 ± 2.2 kg/m2, P = .02), and VLDL levels (0.45 ± 0.15 mmol/dL vs. 0.35 ± 0.15 mmol/dL, P = .05) were observed, without modifying the components of MetS, insulin secretion, and insulin sensitivity. In conclusion, G. sylvestre administration decreased BWt, BMI, and VLDL levels in subjects with MetS, without changes in insulin secretion and insulin sensitivity.	A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (without pharmacological treatment), 30–60 years old, with diagnosis of MetS in accordance with the modified International Diabetes Federation criteria. Patients were randomly assigned to receive G. sylvestre or placebo twice daily before breakfast and dinner in 300 mg capsules for a total of 600 mg per day for 12 weeks. Before and after the intervention, the components of MetS were evaluated as well as BWt, body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein (VLDL)