Cervical

The well proven herbal supplement, astragalus, is reported from trials to both improve the results of treatment and limit drug side effects. Researchers show the re-balancing and restoring immune system health can both reduce risks and encourage better quality of life.

Increased cholesterol activity is one common finding in how many cancers can grow and progress. Comparing statin users to non users has led to reports of lower risks for progression in cervical cancer. From comparision of patient records rather than active trials, those taking specifically lipophilic statins (eg atorvastatin) have been found to have reduced progression and red yeast rice is a widely used natural alternative where a prescription statin is not available.

During a recurrence phase, studies have reported a large drop in zinc levels. The mechanisms behind this include cancer switching immune system activity to allow its growth. So far there are no clinical trials to show effects of supplementation. Healthy pre-diagnostic zinc-selenium levels are strongly linked with better outcomes in several cancers, and now high dose selenium within oncology has shown some striking results, including a pilot trial in gynacologic cancers where a fifth of patients showed sustained progression free responses with chemotherapy. Similarly, many reports have shown iron deficiency in cervical cancer, and link that to dysfuntional iron metabolism seen in high ferritin levels (iron storage proteins). The milk pre-biotic lactoferrin strongly binds iron in the gut helping bring iron into balance.

Use of low dose aspirin has not been closely studied in cervical cancer. There is, however, broad evidence including gynecologic cancers as a group. In ovarian cancer aspirin the highest effects are post-diagnosis, increasing progression free time and reducing overall risks even in advanced stages. There, researchers make the comparision with results seen by adding an immunotherapy drug to chemotherapy treatment. Its apparent that during stages I to III, low dose aspirin has by far the superior benefit. Aspirin can amplify the actions of statins, and the latter are also shown from patient data to have significant benefit in relative survivial for post-diagnostic use in cervical cancer patient data. There are several oncology drug classes often increasing lipid levels.

Mushroom beta glucan increases the activity of the immune system, and recent trials show two thirds of patients are responders to a branded product that cleared HPV infections and radically improved biomarkers of inflammation and better immune system responses. Related to immune responses, they are reportedly also depressed by actions of a specific protein, gal-3, which research shows strongly increased at both primary and metastatic sites of cervical cancer.. This recent finding links with evidence that responders to citrus pectin therapy, about a quarter to half of patients, get measurable improvements from these supplements. Melatonin is a crucial hormone able to rebalance the immune system, its levels are frequently reported to be very depressed in a variety of cancer patients at diagnosis. Even at very late stages, some patients across multiple disease types respond to moderate to high dose melatonin with boh stable disease and improved quality of life.

Another inflammation linked therapy is emerging in functional goods derived from oats or eggs, able to reduce fluid pressure in tumors, a prominent feature of cervical cancer. This is another mechanism driving growth and metastasis, and especially treatment resistance. When it comes to microbiome in cervical cancer, studies show that high diversity very beneficial, both “good” and, surprisingly “bad” strains. Risks are quite significantly lowered, and potentially most of all in a lower inflammation environment.

Systemic inflammation is linked with increased risks for progression, especially in later stages. Both acute type inflammatory responses measured by C-reactive protein, and immune system related neutrophil-to-lymphocyte ratios. Maintaining relatively lower levels of both make a substantial difference. Commonly used Astragalus root has evidence of improving immune system balance and NLR while curcumin and other other functional foods including garlic can help bring down CRP.

The so called Th1/Th2 immune system balance is strongly linked to the progression and to treatment resistance. Molecular iodine solutions are emerging in this area in breast cancer management and seen boosting Th1 anti tumor activity and helping suppress over active Th2 used in resistance. The has improved results in surgery plus chemotherapy and may support increased response immunotherapy (see Supplement Library). For immunotherapy, though less commonly used, the presence of high sodium levels is now identfied as a key marker for success in other cancers. Also in other cancers, AM treatment programs are substantially more effective that PM/evening sessions

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Astragalus actions include protecting and balancing immune responses often with clear effects reported

Sum of complete plus partial responses during oncology increases 25%
A meta-analysis of side by side trials adding astragalus to chemotherapy
Significant reductions reported in side effects of chemotherapy

The results of the meta-analysis show that tumor response significantly improves with Astragalus-containing CHM combined with CT. According to previous reports, the aqueous extract of Astragalus membranaceus has been shown to induce apoptosis of H22 tumor cells and inhibit tumor growth (Li et al., 2012). Polysaccharides from Astragalus membranaceus show potent immunomodulatory activity by stimulating macrophages and increasing the level of cytokines, including the tumor necrosis factor-alpha (TNF-α) and granulocyte-macrophage colony-stimulating factor (GM-CSF)

Red Yeast Rice or a prescription statins reduce both progression and all cause risk

Stain users reported with a 30% increased relative survival rate over a 3 year follow up
Progression Free Survival 60% higher, indicating anti metastatic actions
Sustained use of specifically lipophilic statins which would include lovastatin

Interestingly, we found that the patients who were constantly prescribed with statins had significantly superior survival compared with those who were not prescribed with statins. We found that clinical information of 3 patients who were prescribed with hydrophilic statins was included in the study. Survivals of the 3 patients were significantly inferior compared with the lipophilic statin-use group in the present study. Meanwhile, the survivals were not significantly different with the control group

Aspirin has a majority of analysis in its favor including all-cause mortality

At least a 20% improved overall survival rate with low dose aspirin
Specific data in other gynecologic cancer shows over 30%
Similar reductions in all cause mortality risks

This reveals that aspirin taking is associated with a reduction of cancer deaths of about one fifth in a range of 18 cancers (HR: 0.79) [i.e a 21% reduced risk] in 70 observational studies and OR: 0.67 in 11 studies. The effect of aspirin on all-cause mortality is closely similar (HR: 0.80) in 56 observational studies and OR: 0.57 in 7 studies). A reasonable interpretation of these results is – that at any time after a diagnosis of a wide range of different cancers, about 20% more of the patients who take aspirin are likely to be alive, compared with patients not taking aspirin.,,,We judg...

Selenium is developing in kidney and ovarian cancer, high doses pulsed with oncology drugs

Progression Free Survival increased equally to adding an immunotherapy drug, about 50%
Around 20% of patients are reported with substantially lengthened overall survival results
Notably its also 20% of the patient group actually recieved the dose level targeted for phase II

Of the 3 patients found to have a deleterious mutation in either BRCA1 or BRCA2, one patient experienced a PR with an overall survival (OS) of 79 months, while two patients receiving adjuvant therapy are alive with disease at 81 and 105 months. Interestingly, seven of the nine patients in this tested group without a deleterious germline BRCA1/2 mutation experienced prolonged OS ranging from 60–120 months. Of those seven patients, three patients remain with no evidence of disease at 62, 69, and 114 months, while one patient is alive with disease at 120 months.

Citrus Pectin removes heavy metals such as copper and has its own anti-cancer mechanisms

Palliative stage patients including some uterine cancers
Of those able to complete 2 cycles, a third saw over 4 months stable disease
20% of this subgroup were shown as stable for more than 6 months

In this context, it is remarkable, that in our study the treatment with MCP over a period of 8 weeks was associated with an overall clinical benefit response of 20,7% (6 patients out of 29) as well as an improvement of quality of life. However, the high drop out rate of 20 patients already 8 weeks after the start of treatment has to be considered, reflecting the poor clinical condition of most patients entering our trial and compliance issues in advanced disease.

ZINC and its balance with selenium are closely linked with cancer outcomes in many studies

Disease recurrence reported nearly 5X more likely with insufficient zinc
83% of patients with disease recurrence showed zinc deficiency
Deficiency is reported as independent of diet, treatment or other factors

However, patients with gynecologic cancer exhibited significantly lower serum zinc concentrations following treatment, and patients with recurrent cancer were 4.8 times more likely to develop zinc deficiency than those with nonrecurrent cancer. A serum zinc concentration of <61 μg/dL was an independent predictor of recurrence. Once zinc deficiency occurred, the recurrence rate of zinc deficiency reached as high as 69%. Overall, our study indicates that zinc deficiency is associated with recurrence in gynecological cancers and physicians should monitor zinc levels during disease manageme...

Beta glucans protect and balance immune system activity improving outcomes

AHCC brand mushroom extract clears 2/3 of chronic HPV
Responders see 25-45% increased immune system activity
HPV infections are the driver of most disease recurrence

Results from this phase II study demonstrated that AHCC [mushroom beta glucan] 3 g once daily was effective to support the host immune system to eliminate persistent HPV infections and was well tolerated with no significant adverse side effects reported. The duration of AHCC supplementation required beyond the first negative result needs more evaluation to optimize success for durable outcomes. The suppression of the IFN-β level to less than 20 pg/ml correlated with clearance of HPV infections and merits further evaluation as a clinical tool for monitoring patients with HPV infections.

...

Melatonin trials have shown longer survival rates, even in late stages, and improved side effects

Similar benefits in a wide variety of patients at least some uterine cancers in the data
Specific studies referenced include fascinating late stage trials with high doses
New findings in radiotherapy outcomes tie circadian

This meta-analysis shows a significant positive effect for cancer patients with the use of oral MLT, alone and in combination with chemotherapy. Benefits were seen on survival rates, treatment response rates, and disease progression and on the toxicity profile of a number of chemotherapy agents. It is important to note that these benefits were observed despite the fact that the analysis combined a wide variety of biologically and clinically distinct cancer types, across which MLT nonetheless demonstrated similar results. The large effect sizes and good safety profile of this intervention le...

Antihistamines have large scale analysis of case data supporting their use in most cancers

National scale analysis of patient data with anti-histamines
Loratadine is reported with a 17% risk reduction in uterine cancers
Anti-histamines continue to emerge in clinical trials for several cancers

Loratadine use was also associated with improved tumor-specific survival for some of the immunogenic tumors, especially melanoma, but confidence intervals were wider than for desloratadine…Loratadine use was also associated with improved tumor-specific survival for ovarian cancer…. we believe both desloratadine and loratadine should be tested in randomized clinical trials as treatment of immunogenic tumors, with priority given to trials of desloratadine as treatment of tumors with few therapy options and dismal prognoses

Oat and egg based functional foods are entering early stage clinical trials for several cancers

Low intratumoral fluid pressure predicts 80% reduction in metastatic spread
Functional foods derived from oats and eggs show clear evidence in early trials
Significant reductions in many side effects of oncology drugs are reported

The results of this study indicate that interstitial fluid pressure provides clinically relevant information about the tumor microenvironment and helps predict treatment outcome in patients with cervical cancer receiving radiation therapy. Further studies to clarify the detailed mechanism underlying the biological linkage between interstitial fluid pressure and radiation therapy outcome are warranted. The modulation of interstitial fluid pressure with radiation therapy may provide a valuable therapeutic strategy.

Lactoferrin increases iron balance and reduces anemia rates, countering cancers use of iron

Cancers can progress by upregulating circulating iron stored as ferritin
This report shows large benefit to having normal hemoglobin and relatively low ferritin
It also show large risk reductions for lowering inflammation (CRP biomarker)

The Kaplan-Meier survival analyses of serum ferritin expression revealed that the high ferritin level group had significantly less survival time than normal and low ferritin level groups. It indicates that serum ferritin could predict a poor prognosis for patients with gynecological malignant tumors. The univariable Cox regression analysis identified patients with a high level of ferritin (150
g/L) had a significant correlation with the risk of death compared to the patients with low and normal ferritin levels. Studies have also shown iron elevation in cancer is significant.

Berberine evidence in metabolic health may help counter cancers use of lipids and sugars to grow

Low fasting blood glucose group has half the risk of progression
Related studies show even bigger effects of low inflammation
Berberine can be helpful in both of these levels and more

the present study, we observed that the rate of CR [compete response was significantly lower in hyperglycemic patients … Moreover, on multivariable analysis, hyperglycemia is identified as an independent predictor of CR after NACT [chemotherapy]. In fact, responsiveness to NACT has been noted as the strongest independent prognostic factor for BESCC [early stage cervical cancer] patients . Additionally, this finding is validated by a meta-analysis where Ye et al. pooled data from 18 studies and reported that the response to NACT was significantly associated with better surviva...

Akkermansia gut bacteria levels are becoming a key marker of improved response in oncology, especially immunotherapy

A study comparing benefits of healthy microbiome vs BMI
Diverse gut bacteria gives strongly improved results from oncology
Akkermansia is emerging as an example, in immunotherapy

Gut diversity is a significant factor for predicting OS in CC patients undergoing CRT when BMI is accounted for, and may help explain the “obesity paradox” in cancer response. Studies exploring the relationship between gut diversity, CRT, and treatment efficacy are needed to further understand the role of the gut microbiome in treatment outcomes.

Curcumin has evidence for reducing levels of systemic inflammation used by cancers

Lower inflammation (CRP) levels reported to reduce overall risks by two thirds
An even stronger 75% reduced risk in tumors with low LOX-1 expression
Curcumin has anti-inflammatory evidence reducing CRP and in lab studies even LOX-1

However, our findings are unique and scientifically important because we examined the prognostic significance of pretreatment CRP levels in patients with cancer in relation to LOX-1 levels. We confirmed LOX-1 expression in cervical cancer and showed that higher LOX-1 expression is associated with shorter overall survival in patients with cervical cancer Importantly, CRP was found to be prognostically important only in patients with high LOX-1 expression…Our findings indicate that CRP not only directly stimulates the proliferation of cancer cells via LOX-1 expressed on cancer cells, bu...

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Pathfinder Element	Risk Reduction Factor	Anti-Metastatic	Reduces Side Effects	Research Study
Zinc	>50%	Maybe	Maybe	Link
High dose Selenium	26 - 50%	Probably	Maybe	Link
Red yeast rice/ statin	26 - 50%	Probably	Maybe	Link
Astragalus	Up to 25%	Yes	Yes	Link
Aspirin	Up to 25%	Yes	Maybe	Link
Antihistamines	Up to 25%	Probably	Probably	Link
Melatonin	Up to 25%	Maybe	Yes	Link
Citrus Pectin	Up to 25%	Probably	Probably	Link
Beta Glucans	Indirect - High	Yes	Yes	Link
Gut health including Akkermansia	Indirect - High	Probably	Yes	Link
Lactoferrin	Indirect - High	Probably	Yes	Link
Oat and Egg functional food	Indirect - High	Probably	Yes	Link
Berberine	Indirect - Moderate	Maybe	Maybe	Link
Curcumin	Indirect - Moderate	Maybe	Maybe	Link

Plan Item	Cancers	Background Details	Trial Doses Under Supervision	References
Antihistamines	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Pancreatic, Melanoma, Lymphoma, Esophageal, Bladder	Research indicates desloratadine for localized cancers or loratadine for metastatic. There are examples of ebastine or other alternatives in certain cases. Growing research evidence indicates improved oncology responses. Taken between meals. Low histamine before and during treatment is beneficial.	Active use in clinical trials is still in early phase, follow the dose recommendation for instance 5mg daily unless under medical supervision where higher 10mg doses are frequent
Aspirin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Melanoma, Myeloma, Head and Neck, Bladder, Gallbladder, Non Melanoma Skin, Gastric	Use of low dose 75 or 81mg "baby" aspirin is reported to benefit many cancer types across an average study group, and even all cause mortality. There are some indications of specific "responders" for instance those with existing inflammatory conditions or certain gene expressions. With food.	In a colorectal cancer trial responders were tied to the expression of particular genes (PI3KA). Doses were 160mg	LINK
Astragalus	Breast, TNBC, Lung, Colorectal, Liver, Gastric, Cervical, Endometrial, Pancreatic, Prostate, Kidney, Ovarian, Glioblastoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Bladder, Gallbladder, Thyroid	A typical astraglaus membranaceus supplement may have 50mg of astragaloside IV the main active compound. Its possible with meals can reduce any stomach upset. Use of a standard dose to help immune system balance before treatment.	Here, Astragalus is added to standard oncology in lung cancer Doses are 2-3 tablets of 250mg AMe (Solgar, NJ, USA) minimum for 6 months in this example	LINK
Beta Glucans	TNBC, Lung, Liver, Gastric, Cervical, Pancreatic, Melanoma, Non Hodgkin, Lymphoma, Leukemia	There are many options for mushroom or yeast 1,3/1,6 glucan and branded products include California Gold Immune Defense/Wellmune, AHCC, Biogen/ Yestimun, ImmiFlex, IP6 and many more. A pharma grade product, odetiglucan, is continuing in trials. Take on an empty stomach. Use a standard dose to help balance the immune system before starting treatments.	AHCC is used at 3x1g per day over several months during treatment. Beta glucans are used at 1-2g per day and higher.	LINK
Danshen	Breast, Prostate, Lung, Colorectal, Liver, Leukemia, Myeloma, Bladder	The most common chinese herbal medicine in oncology, also known as red sage. Premium brands such as MCS may recommend 1g twice daily as an ongoing dose. Its possible with meals can reduce any stomach upset. Start a standard dose a couple of weeks before treatment to help balance the immune system.	3 x1g daily between meals , over at least 90 days ideally longer to get maximum benefits according to reported patient outcomes, though even shorter dose period reduced risk	LINK
Green Coffee Extract	Glioblastoma	Supplements vary in terms of their chlorogenic acid content, it can be up to 50%. Quality brand might specify this level under their recommended intake. High dose commercial brands may be over 1000mg total, take before meals.	Analysis across trials reports metabolic health benefits start are higher at >500mg or daily. High chlorogenic acid content supplements eg Svetol have been trialed safely for 12 weeks at 200mg x 5 daily dose. As always, be aware of possible drug interactions	LINK
Red Yeast Rice Or statin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Endometrial, Melanoma, Leukemia, Myeloma, Head and Neck, Esophageal	Red yeast rice is equivalent to lovastatin. Doses are essentially on the products, and there are many premium brands with guaranteed level of monokolin k around 3mg. A common theme is findings is those with improved cholesterol are "responders". With meals. Start cholesterol and inflammation reducing statins early.	Trial data is often case studies with multiple statins where lovastatin has average effects. Often atorvastatin and sometimes simvastatin come out on top. Research ususally reports intermediate doses ( 10-20mg) are effective but there are examples indicating higher doses under supervision.	LINK
Turkey Tail	Lung, Colorectal, Kidney, Liver, Gastric	A typical premium supplement such as MCS recommend 700mg twice daily with food. Mushroom based glucans can help balance immune response so start them before your treatment.	Pharma grade turkey tail, e.g PSP/ PSK/ Krestin is typically used at 3x 1g daily during oncology, up to 36 months and more. Trials in breast cancer have also used 3,6 and 9g daily regimes in 6 week periods	LINK
Vitamin D3	Breast, TNBC, Prostate, Lung, Colorectal, Gastric, Ovarian, Pancreatic, Glioblastoma, Melanoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Esophageal, Bladder	High dose commercial formulae can be 10,000IU. Which might be achieved by as little as 10 to 20 minutes in sunshine. Vitamin K2 is advised with D3. Take with some food containing fat. Its important to ramp these up before oncology treatments, and sustain the higher levels over time. Add magnesium for best absorption and metabolism.	The VITAL trial used 2000IU and discussed the potential of higher doses to increase responders especially higher BMI/ body weight. Whilst in prostate cancer there are trials demonstrating at least 10,000IU is required to see activity reducing PSA levels	LINK
Melatonin	Breast, TNBC, Prostate, Lung, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Glioblastoma	Commonly used in 10 to 40mg daily range no reported side effects, typically an hour before sleep.	Moderate and high dose trials report no significant side effects even at 1000mg daily	LINK
Citrus Pectin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Non Hodgkin, Leukemia, Myeloma, Head and Neck, Esophageal, Bladder, Gallbladder, Thyroid, Gastric	Trials use a recommended dose up to 5g x3 daily and no significant side effects. Taken 30 minutes before or 90 minutes after food. Ideally, start PectaClear or similar products at least 4 week before treatment to reduce heavy metals. But sustain zinc with supplementation	Even in children age 5 to 12 the daily regime 3 x 5g was safe and effective for heavy metal chelation	LINK
Soy Isoflavones	Breast, Prostate, TNBC	Often dietary sources, tofu and soy based and no evidence of side effects. Supplements generally with food.	In a clinical trial setting up to 900mg with no issues	LINK
Fermented Wheatgerm	Prostate, Colorectal, Melanoma	Trials are with Avemar brand products with no significant safety concerns reported	Typical dose regimes may be aroung 9g daily over longer time periods for instance 12 months	LINK
Iodine	Breast, TNBC	General usage around 1000mcg or 1mg generally with food	Successful pilot studies in breast cancer use 5mg molecular Iodine daily for the duration of therapy	LINK
Lactoferrin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Endometrial, Pancreatic, Glioblastoma, Melanoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Bladder, Esophageal, Gallbladder, Thyroid	200mg typical use daily , eg 10ml liposomal formula ideally 30 minutes before meals or 2 hours after. No side effects of note. Start this immediately to achieve and maintain healthy iron absorption, avoid deficiencies and reduce cancer related ferritin levels.	During oncology doses of up to 3g to 9g daily, even higher, have been used with significant side effects	LINK
Selenium	Breast, Lung, Kidney, Ovarian, Cervical, Endometrial, Pancreatic, Melanoma, Head and Neck	Supplements are 200ug doses and similar amounts from about 3 brazil nuts. Start buildin gup your levels immediately and keep them high during oncology. Selenium toxicity is a consideration for high doses over time, so seek medical advice. Ideally taken with meals.	This trial used 2500 to 4000ug 2x daily for 14 days then once daily in kidney cancer with no dose limiting toxicity	LINK
Vitamin B3	Liver, Gastric, Glioblastoma, Non Hodgkin, Lymphoma, Leukemia, Non Melanoma Skin	Typically 500mg for nicotinamide (niacinamide) form of B3 taken ideally with meals	Do not differ from standard doses, here 500mg twice daily related to skin cancer	LINK
Akkermansia	Breast, TNBC, Prostate, Lung, Kidney, Liver, Ovarian, Cervical, Pancreatic, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Gastric	Commercial products may be at 10B CFU typically 30 minutes before or 2 hours after food. Ramp up levels with diet and moderate supplementation before treatments, especially immunotherapy.	Under development. Results in oncology indicate this is one of many helpful guy bacteria. careful consideration and particularly following use of antibiotics. Diversity is crucial.	LINK
Berberine	Kidney, Liver, Cervical, Pancreatic, Non Hodgkin, Leukemia, Myeloma, Head and Neck, Esophageal, Gallbladder, Thyroid, Non Melanoma Skin, Melanoma, Bladder	A natural anti-diabetic used frequently at 400mg daily and above, shortly before meals	In metabolic health trials frequentlu use up to 500mg at 3 times daily .	LINK
Curcumin	Colorectal, Liver, Non Hodgkin, Myeloma, Bladder, Gallbladder, Non Melanoma Skin, TNBC, Breast, Prostate, Lung, Kidney, Gastric, Ovarian, Cervical, Endometrial, Glioblastoma, Melanoma, Lymphoma, Leukemia, Head and Neck, Thyroid	Doses from 500mg to 2000mg frequently seen. Piperine fron black pepper improves absorption, highly bioavailable formulae are available. Ideally with a meal containing fat.	Higher doses in trials are frequently 2 of 4 g daily (+40 mg piperine) during oncology for instance here at 3 periods of 30 days	LINK
Quercetin	Glioblastoma, Myeloma	Can be found in a healty diet. Supplements often 500 or 1000mg and can be taken with tocotrienols for enhanced absorption, a form of vitamin E . Some evidence that Quercetin should be pulsed on/off.	Clincial trials have safely used up to 5g daily in adults, and 1 to 4g for rare forms of paediatric anemia	LINK
Urolithin A	Prostate, Lung, Colorectal, Kidney, Gastric, Glioblastoma, Melanoma, Myeloma, Gallbladder, Head and Neck	Typical commercial brands run at 500mg once or twice daily, with or without food, some brands suggest with meals	Trials eg in anti-aging science use the same dose range	LINK
Oat and Egg Functional Food	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Cervical, Pancreatic, Glioblastoma, Melanoma, Head and Neck, Gallbladder	Follow supplier guidance on dosage and use. https://shop.lantmannenfunctionalfoods.com/? Lowering tumor fluid pressure helps treatments work, start these before your treatment if possible. Use egg based salovum for short term "pulse" during therapy and oat products for sustained use over longer time periods	This trial in glioblastoma used 16g egg based Salovum four times daily. It discusses lowering that regime in follow on trials.	LINK
Coffee	Breast, Prostate, Colorectal, Liver, Non Melanoma Skin	Most dietary studies use standard 8oz servings as a guide. In many cases the findings are that benfits increase with intake. But in some cases such as prostate cancer there are important details in the PATHFINDER	No, but chlorogenic acid and, separately, green coffee extracts are used at 400mg and up to 2000mg
Flax	TNBC, Ovarian	Crushed flaxseed alone or in foods around 1/4 cup daily	Doses up to 50g daily in clinical trials for various diseases. Here a fairly typical 30g regime in inflammatory liver diseases	LINK
Propolis	Breast	Typical supplements range from 400 to 1000mg	Here 400mg x3 daily help recovery from radiotherapy	LINK
Walnuts	Prostate, Colorectal, Melanoma, Head and Neck	Dietary food item shown even at low useage to be helpful even at a few oz per week	Here, 2oz (56g) daily showed measurable activity in breast cancer	LINK
Mushroom	Prostate	Both dietary sources and many commercial supplements normally taken with food	In this example some patients saw responses between 8 and 14g daily of button mushroom extract	LINK
Zinc	Kidney, Ovarian, Cervical, Endometrial, Head and Neck, Non Melanoma Skin	Commercial supplements vary considerably . Moderate 20mg range generally advised	No
Intravenous HIgh Dose Vitamin C	Pancreatic, Glioblastoma	Commercial supplements vary. A moderate range around 20mg with food is generally accepted as safe.	Same as general guidance
Alpha Ketoglutarate	Melanoma, Kidney, TNBC, Non Hodgkin, Lymphoma	Typical usage is 1000mg daily with or without food, safety is good. Its especially important to ramp up and sustain your levels for maximum immunotherapy responses.	Larger doses of several grams have been safely used in various trials including here in bone disease at 6g daily	LINK
Horse Chestnut (Escin)	Thyroid	Common 300 to 600mg supplements contain 50 to 120mg of active compound, escin taken with food	Escin up to 150mg daily in vascular health. In oncology 0.6 mg/kg/day for 9 days, intravenous injection has been used, high absorption premium supplement would reacj this level	LINK

Impact	What	Why	Dose	Impact summary	Later stage treatment/ targeted drugs	Activity against Lung metastases?	Anti-metastatic in general	Higher doses eg in clinical trials	Other comments or sources
>50%	Lactoferrin	Progression is strongly linked to low iron levels, which are weakend immensely by the treatments	10ml lipsomal LF daily, ideally on empty stomach	BOTH normal hemoglobin and low ferritin is a 3X or more impact to sustained treatment responses	Evidence shows essential need for well balanced iron levels, during chemo and targeted drugs both	Yes, about a 25% reduced risk and 20% reduced side effects of chemotherapy	Low iron levels strongly linked to increased metastatic activity	Only with chemo. 1.5g lactoferrin twice daily 1.5 g for three 6-week cycles used in lung cancer	Hemoglobin over 120g/dL is used as the level in studies. 130 to 150g/dL would be good. Low ferritin levels, and iron inflammatory state, are also needed. LF helps with both
>50%, lower with chemo	Zinc during immunotherapy	Essential for supporting immune response	Use high absorption formula 20 to 40mg	Newly reported as doubling response in other cancers, its likely to transfer to cervical cancer	Maintaining Zinc is always important including with chemo	Yes the zinc trial is mainly for lung cancer indicating its relevance	Maybe	Unclear but moderation is probably good	About twice the response rates with good zinc levels in other cancers
>50%	Sodium during immunotherapy	Boosts and activates immune response, enables strong anti tumor activity	With diet around 6-8g daily, need to be at 140-145mmol/l	Astonishing 9X higher response rate in patients with good 140mmol/l sodium, actions should be universal for immunotherapy	This is where sodium is an independent biomarker yes, active clinical trials still pending	Yes, regression of lung mets is part of Complete Response	Surprisingly, LOW sodium has growing evidence of increasing metastatic activity	This is not defined but up to 2/3 of patients during immunotherapy see low salt levels	There is a major risk that immunotherapy drugs lead to sodium deficiency after 4 to 5 weeks on therapy. So a higher intake is indicated
>50%	Inosine with immunotherapy	Immune cell activation increases	500 to 1500mg	Specific to immunotherapy, large benefit but being explored with chemo	May help reverse resistance to chemo, there is an ongoing trial	Yes the first trial is mainly for lung cancer indicating its relevance	Ongoing trial in breast cancer may provide evidence yes	Not to date	Trial with chemo at 200mg x 3 per day. But this has high safety
>50% for immunotherapy, 25-50% chemo	Vitamin D3 with immunotherapy	Boosts and activates immune response, enables strong anti tumor activity	At least 10,000IU daily with meals	For all treatments the link to higher D3 is clear and in immunotherapy data in other cancers shows around 2X	Across many other cancer types higher D3 levels are reported to improve results yes	Yes, again regression of lung mets is part of increased response. And lung cancer themselves are similar affected	Yes	Research is into higher doses in order to increase the proportion of "responders"	Existing trials assessed 30ng/ml as sufficient. Other studies actively discuss supplementation to reach at least. 40ng/ml. Be sure to include magnesium and K2
>50% with immunotherapy	Alpha Ketoglutarate (Ca-AKG) during immunotherapy	Helps immunotherapy drugs overcome evasion	500mg x2 daily any time	Patients with high AKG levels have around 2X response rates	Evidence so for for PD-1 blockade for instance nivolumab and pembrolizumab	AKG has related evidence in anti aging science and is gaining in attention in researchers work	likely yes, there is lab evidence for this	YES Load up Ca-AKG before and during therapy	AKG may be lowered by metformin. This anti aging supplement has excellent safety
>50% with immunotherapy, indirect-high overall	Gut health including akkermansia	Indirect importance of gut bacteria is crucial in immunotherapy	Supplier dose, moderate level	Crucially, metastatic spread to the bone is linked to lack of a diverse microbiota including low akkermansia.	Has become a recognized factor in immunotherapy success, with likely strong importance here too	YES , 50 to 100% higher immunotherapy response with akkermansia in lung cancers	Yes	No, evidence is to apply moderation with supplements and lead with diet	Foundation here is high vegetable and high fiber diet
>50%	Iodine solution (with surgery)	Immune system activation	5mg liquid iodine during treatment window, start a month before	The research so far is focused on combination with breast cancer surgery	So far this is related to surgery.	No current research on this	Maybe	Not reported	To be seen if iodine solution is effective in chemo or radiotherapy. For surgical procedures it has evidence in breast cancer likely to carry over. Start a month before
26-50% (probably higher with immunotherapy)	Red yeast rice or statin	Anti-lipid and anti-inflammation	Per the supplier guidance. Use a premium brand	Multiple studies from patient records. Effects mainly for post-dagnostic use especially LDL "responders"	Statins tend ot improve responses to targeted drugs treatments in other cancers	Yes, atorvastatin reported with a 59% improved risk level. Statin effects in general improve immunotherapy	Probably	There are some reports of dose dependency, specifically that low dose statin is not effective	Useful to know if LDL dropped with statin use. Interesting synergies with nattokinase (Supplement Library)
26-50% estimated	Anti-inflammatory diet	Lowering inflammation is crucial, low CRP is a major marker for better outcomes	Continuous	Research evidence continues to grow for mainly vegetarian diet with higher fiber content	Always a valid approach	No data but likely helpful	Yes	Low CRP linked to up to 75% impact, more is better	Also read Lifestyle section for view on evidence in diets and eating patterns
26-50% estimated	Structured exercise	Multiple proposed anti-cancer actions	At least 2.5 hours moderate intensity per week	Yes there are new publications supporting this effect	Probably, there is clear evidence pointing to benefit	No data but likely helpful	Probably	No	New studies confirming this in other cancers
26-50%	Treatment timing	AM vs PM matters	All sessions of immunotherapy	Yes a 43% benefit to morning treatment vs afternoon	Yes, for immunotherapy in metastatic kidney cancer	Yes this includes reduction in lung mets for kidney cancers	?
Up to 25%	Beta Glucans - AHCC	Balance and help regenerate immune system, and reduce side effects	1 or 2x 250mg California Gold Immune Defense with Wellmune	Effects on improved immune response and inflammation	Yes the effects are also evident in advanced stage treatments	Indirect - there is improved immunotherapy response in lung tumors with beta glucans	Indirectly, lower NLR is linked to lower metastatic activity
Up to 25%	Desloratadine	Help immune system function and side effects	1 or 2 x 5mg daily	Large scale analysis of patient records reports this effect	Yes , infact effects are shown to increase over time	Indirectly - an 80% and much lower side effects (loratadine) in lung cancer immunotherapy	Probably	No current evidence but generally safe	Loratadine is reported as effective in metastatic disease stage . see Supplements Library
Up to 25%	Low dose Aspirin	Reduce blood clotting improves vascular health	75mg	There is evidence for lower progression and recurrence risks and	Yes the effects are also evident in advanced stage treatments	Yes and also a third lower progression in lung cancer itself	Yes	No	Nattokinase+curcumin is a natural anti-clotting and anti-metastatic. See Nattokinase in Supplements Library
Up to 25%	Citrus Pectin / Pectaclear	Reduce copper and harmful metals, also help sugar metabolism and microbiome	Copper removal with Pectaclear at 2g x 2 daily on an empty stomach	Heavy metals strongly linked to poor prognosis. Possible anti-metastatic activity too.	Lower copper is clearly linked to better immunotherapy responses in other cancers	Yes, lower copper is better and effects are more than 50%	Probably	Follow supplier program	Exposure to tobacco may contribute to heavy metal build up in some patients, and reducing this is crucial for those who are at risk
Up to 25%	Propolis ( with radiotherapy)	Protective actions against radiation induced cell damage	Per supplier	The data available shows very beneficial support for radiotherapy	Focused on radiotherapy	No data on this	Maybe	Trials have used 400mg x3 daily doses
Up to 25%	Astragalus	Natural immune system balance and activity, studies are in chemotherapy but also inflammatory marker NLR	At least 500mg daily (50mg astragalaside)	There are astonishingly improved outcomes with low NLR markers, astraglus can assist that	Astragalus has good results in chemo and TKI targeted drugs in several cancers	Halves progression risks in lung cancer alongside TKI treatment indicating probable effects in lung lesions	Yes	Prescribed doses of 3g per day are typical in first months	Based on evidence in lung cancer, excellent alternative with chemo to achieve "immuntherapy" type benefits (Supplements Library)
Up to 25%	Melatonin	Boosts natural immune system activity	Often 10 to 20mg evenings	Higher doses are reported with striking effect in late stages. More is needed on continuous use.	No current evidence	No data on this	Maybe	100mg and even 1g have shown responses in late stage trials
Indirect-high	("High" Dose) Selenium	Immune system support and more. Higher does may weaken tumor resistance	200 mcg with meals is RDA, high dose is several times this	Pilot trial reports remarkable effects in about a quarter of ovarian cancers. Including cases of long term sustained remission	This is not researched at this point	Yes these effects can include clearing of lung lesions	Probably	Both OvC and Kidney cancer trials ongoing with these "high" doses	9 to 12X the daily allowance 2 days before chemo is used here. This could produce side effects so consult with your oncology team on this
Indirect - High	Oat and Egg functional foods (especially with chemotherapy)	Helps treatment side effects and potentially weakens physical tumor resistance	Per supplier	Clinical trial ongoing primarily to reduce side effects. Especially chemo related and reducing metastatic activity	No current evidence	Pending clinical study results in other cancers	Probably	No data	Ongoing phase III trial looking at reducing treatment side effects especially gastrointestinal....may reduce tumor resistance
Indirect - Moderate	Curcumin	Good supplement in anti-inflammatory diet	Per supplier. Get a high absorption formula	Has potential copper removal actions and more	No current evidence	Indirectly via benefits in lowering CRP	Maybe	Follow supplier program
Indirect - Moderate	Berberine					Indirectly via imroved lipid and glucose metabolism
>50%	Magnesium with Immunotherapy	This is new research just breaking

Treatment often starts with some combination of chemo and radio therapy. With advancing disease, immunotherapy and targeted drugs may be recommended for instance pembrolizumab (Keytruda) and with it can be bevacizumab (Avastin). The results of adding these drugs to chemotherapy are much better than in most other cancers, about twice as effective with overall risk reductions around 40% reported https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.5500 And adding the targeted drug as well, typically bevacizumab, is also reported with additional risk reductions around 25% https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.5531

Your PATHFINDER brings together research that may help maximize the effects of chemotherapy, immunotherapy and targeted drug treatments. Even in reducing the risk of metastatic spread. The IMPACTS tab summarizes these and can lead to Many more Good days by helping these treatments work, reducing your risk for progression and by easing treatment side effects. If you do elect both chemotherapy and immunotherapy/ targeted drugs, you can continue to look for ways to increase the results and reduce possible toxicities;

Be sure to fully read and absorb the PATHFINDER and its Impacts summary
If you have metastatic sites take a look into the corresponding Pathfinder for those too, for inspiration.
Use the Supplement Library Index and filter on “Chemotherapy”, “Immunotherapy” and “Targeted drugs” for ideas.
The Foods Library can complement your plan, including anti-metastatic strategies and metabolic health
In the Lifestyle section gathers fascinating evidence for diets and exercise
The PLANS section may have information from what others are doing and have learned

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