Endometrial

Increased cholesterol activity is one common finding in how many cancers can grow and progress. Comparing statin users to non users has led to reports of major benefits in endometrial cancer progression, particularly in post diagnosis users who have taken them for the long term. Atorvastatin tends to be the most researched prescription statin, and where this is lacking the widely available natural supplement form of lovastatin is red yeast rice. In other cancers it has been found that statin “responders” who see a drop in LDL get the largest risk reductions.

Evidence for low dose aspirin use, also from comparing patient records, shows that some patients see strong risk reductions. Aspirin can amplify the actions of statins, and the latter are also reported have significant postive effects for post-diagnostic use. There are several oncology drug classes often increasing lipid levels.

During a recurrence phase, studies have reported a large drop in zinc levels. The mechanisms behind this include cancer switching immune system activity to allow its growth. So far there are no clinical trials to show effects of supplementation. Healthy pre-diagnostic zinc-selenium levels are strongly linked with better outcomes in several cancers, and now high dose selenium within oncology has shown some striking results, including a pilot trial in gynecologic cancers where a fifth of patients showed sustained progression free responses with chemotherapy.

Immune response is often depressed by a specific protein associated with inflammatory response, galectin-3, which research shows is increased in its activity by endometrial cancers. This recent finding links with reports that responders to citrus pectin therapy, about a quarter to half of patients have stablized progression even in late stages. Melatonin levels are, in contrast, frequently very depressed in a variety of cancer patients at diagnosis. Here again, even in very late stages, some patients respond to moderate or high dose melatonin with stable disease and improved quality of life.

Endometrial cancers often cause dysregulated iron metabolism, and the enzyme like protein ferritin levels rise during progression. Iron is then stored by tumors to fuel their growth. Which can also be seen during iron deficiency or anemia which are also significant risk factors. The milk based prebiotic lactorferrin binds iron strongly in the gut and increases a healthy iron balance, so called homestasis. This counteracts the inflammational activity of cancers.

Systemic inflammation is linked with increased risks for progression, especially in later stages. Both acute type inflammatory responses measured by C-reactive protein, and immune system related neutrophil-to-lymphocyte ratios. Maintaining relatively lower levels of both make a substantial difference. Commonly used Astragalus root has evidence of improving immune system balance and NLR while curcumin and other other functional foods including garlic can help bring down CRP.

The so called Th1/Th2 immune system balance is strongly linked to the progression and to treatment resistance. Molecular iodine solutions are emerging in this area in breast cancer management and seen boosting Th1 anti tumor activity and helping suppress over active Th2 used in resistance. The has improved results in surgery plus chemotherapy and may support increased response immunotherapy (see Supplement Library). For immunotherapy, though less commonly used, the presence of high sodium levels is now identfied as a key marker for success in other cancers. Also in other cancers, AM treatment programs are substantially more effective that PM/evening sessions

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Red Yeast Rice or where possible a prescription statin have multiple beneficial actions including all-cause risks

Patient data shows much improved outcomes on those using statins
Highest at 57% risk reductions for post diagnostic users, and any dose
Risk reductions increased with long term use indicating sustained effects

Associations did not differ substantially by intensity or cumulative amount of statin use. In secondary analyses including prediagnosis statin use, we observed reduced mortality among both continuing (pre- and postdiagnosis) users (HR 0.70) and new (post diagnosis only) users (HR 0.43) [i.e 57% risk reduction] compared to “never users.” In sensitivity analyses with fixed exposure periods after the endometrial cancer diagnosis, the inverse association was more pronounced more than 5 years after the diagnosis. Our findings suggest that statin use may be associated with improved survival i...

Aspirin has a majority of analysis in its favor including all-cause mortality

Up to 77% risk reductions in progression are reported with low dose aspirin
Higher BMI levels associated with measurable benefits
Early stage, younger and especially those treated with radiotherapy

This study demonstrated that low-dose aspirin use was associated with improved survival outcomes in women with endometrial cancer. This effect of low-dose aspirin on survival was particularly prominent in young and obese women as well as in those with low-grade disease. Our study also showed that low-dose aspirin users had higher survival rate compared with nonusers among women who received postoperative radiotherapy

Astragalus actions include protecting and balancing immune responses often with clear effects reported

Adding astragalus is reported to increase overall survival rates by 33%
Clear biomarker evidence of increase immune response, lower inflammation
Significant reduction of side effects of therapy

Radix Astragali injection combined with megestrol acetate tablets has obvious therapeutic effects against endometrial cancer. Through vaginal ultrasonography and MRI, it can significantly improve the size, shape, and blood flow signals of patients’ lesions, reduce the level of serum inflammatory factors and tumor markers HE4 and CA125, reduce the incidence of toxic and side reactions, improve the patient’s immunity, improve the patient’s condition significantly, and prolong the survival time of patients

Selenium is developing in kidney and ovarian cancer, high doses pulsed with oncology drugs

Progression Free Survival increased equally to adding an immunotherapy drug, about 50%
Around 20% of patients are reported with substantially lengthened overall survival results
Notably, 20% of the patient group actually recieved the dose level targeted for phase II

Of the 3 patients found to have a deleterious mutation in either BRCA1 or BRCA2, one patient experienced a PR with an overall survival (OS) of 79 months, while two patients receiving adjuvant therapy are alive with disease at 81 and 105 months. Interestingly, seven of the nine patients in this tested group without a deleterious germline BRCA1/2 mutation experienced prolonged OS ranging from 60–120 months. Of those seven patients, three patients remain with no evidence of disease at 62, 69, and 114 months, while one patient is alive with disease at 120 months.

Citrus Pectin removes heavy metals such as copper and has its own anti-cancer mechanisms

Palliative stage patients including some uterine cancers
Of those able to complete 2 cycles, a third saw over 4 months stable disease
20% of this subgroup were shown as stable for more than 6 months

However, in consideration of this background, it is remarkable that even 12 (10) out of 49 patients showed a stabilized disease over a period of at least 8 (16) weeks of oral MCP treatment. Moreover, 6 patients had a SD for a period longer than 24 weeks. Furthermore, the 50% decrease of the serum PSA level after 16 weeks of treatment associated with a significant increase of clinical benefit, quality of life and reduction in pain in one patient with far advanced hormone-refractory prostate cancer indicates antitumoral efficacy even in patients with far advanced solid tumors

ZINC and its balance with selenium are closely linked with cancer outcomes in many studies

Disease recurrence reported nearly 5X more likely with insufficient zinc
83% of patients with disease recurrence showed zinc deficiency
Deficiency is reported as independent of diet, treatment or other factors

However, patients with gynecologic cancer exhibited significantly lower serum zinc concentrations following treatment, and patients with recurrent cancer were 4.8 times more likely to develop zinc deficiency than those with nonrecurrent cancer. A serum zinc concentration of <61 μg/dL was an independent predictor of recurrence. Once zinc deficiency occurred, the recurrence rate of zinc deficiency reached as high as 69%. Overall, our study indicates that zinc deficiency is associated with recurrence in gynecological cancers and physicians should monitor zinc levels during disease manageme...

Melatonin trials have shown longer survival rates, even in late stages, and improved side effects

Similar benefits in a wide variety of patients with some gynecalogic cancers in the data
Specific studies referenced include fascinating late stage trials with high doses
Strong link between depressed levels of melatonin and endometrial cancer

This meta-analysis shows a significant positive effect for cancer patients with the use of oral MLT, alone and in combination with chemotherapy. Benefits were seen on survival rates, treatment response rates, and disease progression and on the toxicity profile of a number of chemotherapy agents. It is important to note that these benefits were observed despite the fact that the analysis combined a wide variety of biologically and clinically distinct cancer types, across which MLT nonetheless demonstrated similar results. The large effect sizes and good safety profile of this intervention le...

Lactoferrin increases iron balance and reduces anemia rates, countering cancers use of iron

Being in the lower ferritin group more than halves risk levels
Excess circulating iron stored in ferritin indicates progression
At the same time, iron deficiency can be a recurring challenge

Through our research, we found that the high expression of serum ferritin level was not only related to low DFS and OS in patients with endometrial carcinoma, but also related to the high-risk factors of endometrial carcinoma recurrence. So serum ferritin levels may be used to predict the poor prognosis of patients with endometrial carcinoma…Therefore, SF [serum ferritin] may be used as a specific biomarker for preoperative evaluation of high-risk factors and postoperative personalized treatment of patients with EC, so as to improve the prognosis of EC.

Curcumin has evidence for reducing levels of systemic inflammation used by cancers

Lower inflammation levels lower all cause and cancer risk
An effect of at least half in cancer progression risks
Approximately 40% lower all cause mortality also reported

Here, we show evidence for the potential utility of CRP as a prognostic biomarker in endometrial cancer. Women with a high pre-treatment CRP at a decision threshold of 5.5 mg/L had a 68% increase in overall mortality and a two-fold higher cancer-specific mortality risk compared to those with low CRP. Absolute lymphocyte count, NLR, MLR and SII were associated with aggressive tumor parameters including stage, histology, grade, LVSI and deep myometrial invasion, but when these and clinical prognostic factors were controlled for, there was no evidence that lymphocyte-based scores are associate...

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GUIDE

Pathfinder Element	Risk Reduction Factor	Anti-Metastatic	Reduces Side Effects	Research Study
Aspirin	>50%	Yes	Maybe	Link
Zinc	>50%	Maybe	Maybe	Link
High dose Selenium	26 - 50%	Probably	Maybe	Link
Astragalus	26 - 50%	Yes	Yes	Link
Red yeast rice/ statin	26 - 50%	Probably	Maybe	Link
Melatonin	Up to 25%	Maybe	Yes	Link
Citrus Pectin	Up to 25%	Probably	Probably	Link
Lactoferrin	Indirect - High	Probably	Yes	Link
Curcumin	Indirect - Moderate	Maybe	Maybe	Link

Plan Item	Cancers	Background Details	Trial Doses Under Supervision	References
Antihistamines	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Pancreatic, Melanoma, Lymphoma, Esophageal, Bladder	Research indicates desloratadine for localized cancers or loratadine for metastatic. There are examples of ebastine or other alternatives in certain cases. Growing research evidence indicates improved oncology responses. Taken between meals. Low histamine before and during treatment is beneficial.	Active use in clinical trials is still in early phase, follow the dose recommendation for instance 5mg daily unless under medical supervision where higher 10mg doses are frequent
Aspirin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Melanoma, Myeloma, Head and Neck, Bladder, Gallbladder, Non Melanoma Skin, Gastric	Use of low dose 75 or 81mg "baby" aspirin is reported to benefit many cancer types across an average study group, and even all cause mortality. There are some indications of specific "responders" for instance those with existing inflammatory conditions or certain gene expressions. With food.	In a colorectal cancer trial responders were tied to the expression of particular genes (PI3KA). Doses were 160mg	LINK
Astragalus	Breast, TNBC, Lung, Colorectal, Liver, Gastric, Cervical, Endometrial, Pancreatic, Prostate, Kidney, Ovarian, Glioblastoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Bladder, Gallbladder, Thyroid	A typical astraglaus membranaceus supplement may have 50mg of astragaloside IV the main active compound. Its possible with meals can reduce any stomach upset. Use of a standard dose to help immune system balance before treatment.	Here, Astragalus is added to standard oncology in lung cancer Doses are 2-3 tablets of 250mg AMe (Solgar, NJ, USA) minimum for 6 months in this example	LINK
Beta Glucans	TNBC, Lung, Liver, Gastric, Cervical, Pancreatic, Melanoma, Non Hodgkin, Lymphoma, Leukemia	There are many options for mushroom or yeast 1,3/1,6 glucan and branded products include California Gold Immune Defense/Wellmune, AHCC, Biogen/ Yestimun, ImmiFlex, IP6 and many more. A pharma grade product, odetiglucan, is continuing in trials. Take on an empty stomach. Use a standard dose to help balance the immune system before starting treatments.	AHCC is used at 3x1g per day over several months during treatment. Beta glucans are used at 1-2g per day and higher.	LINK
Danshen	Breast, Prostate, Lung, Colorectal, Liver, Leukemia, Myeloma, Bladder	The most common chinese herbal medicine in oncology, also known as red sage. Premium brands such as MCS may recommend 1g twice daily as an ongoing dose. Its possible with meals can reduce any stomach upset. Start a standard dose a couple of weeks before treatment to help balance the immune system.	3 x1g daily between meals , over at least 90 days ideally longer to get maximum benefits according to reported patient outcomes, though even shorter dose period reduced risk	LINK
Green Coffee Extract	Glioblastoma	Supplements vary in terms of their chlorogenic acid content, it can be up to 50%. Quality brand might specify this level under their recommended intake. High dose commercial brands may be over 1000mg total, take before meals.	Analysis across trials reports metabolic health benefits start are higher at >500mg or daily. High chlorogenic acid content supplements eg Svetol have been trialed safely for 12 weeks at 200mg x 5 daily dose. As always, be aware of possible drug interactions	LINK
Red Yeast Rice Or statin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Endometrial, Melanoma, Leukemia, Myeloma, Head and Neck, Esophageal	Red yeast rice is equivalent to lovastatin. Doses are essentially on the products, and there are many premium brands with guaranteed level of monokolin k around 3mg. A common theme is findings is those with improved cholesterol are "responders". With meals. Start cholesterol and inflammation reducing statins early.	Trial data is often case studies with multiple statins where lovastatin has average effects. Often atorvastatin and sometimes simvastatin come out on top. Research ususally reports intermediate doses ( 10-20mg) are effective but there are examples indicating higher doses under supervision.	LINK
Turkey Tail	Lung, Colorectal, Kidney, Liver, Gastric	A typical premium supplement such as MCS recommend 700mg twice daily with food. Mushroom based glucans can help balance immune response so start them before your treatment.	Pharma grade turkey tail, e.g PSP/ PSK/ Krestin is typically used at 3x 1g daily during oncology, up to 36 months and more. Trials in breast cancer have also used 3,6 and 9g daily regimes in 6 week periods	LINK
Vitamin D3	Breast, TNBC, Prostate, Lung, Colorectal, Gastric, Ovarian, Pancreatic, Glioblastoma, Melanoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Esophageal, Bladder	High dose commercial formulae can be 10,000IU. Which might be achieved by as little as 10 to 20 minutes in sunshine. Vitamin K2 is advised with D3. Take with some food containing fat. Its important to ramp these up before oncology treatments, and sustain the higher levels over time. Add magnesium for best absorption and metabolism.	The VITAL trial used 2000IU and discussed the potential of higher doses to increase responders especially higher BMI/ body weight. Whilst in prostate cancer there are trials demonstrating at least 10,000IU is required to see activity reducing PSA levels	LINK
Melatonin	Breast, TNBC, Prostate, Lung, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Glioblastoma	Commonly used in 10 to 40mg daily range no reported side effects, typically an hour before sleep.	Moderate and high dose trials report no significant side effects even at 1000mg daily	LINK
Citrus Pectin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Ovarian, Cervical, Endometrial, Pancreatic, Non Hodgkin, Leukemia, Myeloma, Head and Neck, Esophageal, Bladder, Gallbladder, Thyroid, Gastric	Trials use a recommended dose up to 5g x3 daily and no significant side effects. Taken 30 minutes before or 90 minutes after food. Ideally, start PectaClear or similar products at least 4 week before treatment to reduce heavy metals. But sustain zinc with supplementation	Even in children age 5 to 12 the daily regime 3 x 5g was safe and effective for heavy metal chelation	LINK
Soy Isoflavones	Breast, Prostate, TNBC	Often dietary sources, tofu and soy based and no evidence of side effects. Supplements generally with food.	In a clinical trial setting up to 900mg with no issues	LINK
Fermented Wheatgerm	Prostate, Colorectal, Melanoma	Trials are with Avemar brand products with no significant safety concerns reported	Typical dose regimes may be aroung 9g daily over longer time periods for instance 12 months	LINK
Iodine	Breast, TNBC	General usage around 1000mcg or 1mg generally with food	Successful pilot studies in breast cancer use 5mg molecular Iodine daily for the duration of therapy	LINK
Lactoferrin	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Gastric, Ovarian, Cervical, Endometrial, Pancreatic, Glioblastoma, Melanoma, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Bladder, Esophageal, Gallbladder, Thyroid	200mg typical use daily , eg 10ml liposomal formula ideally 30 minutes before meals or 2 hours after. No side effects of note. Start this immediately to achieve and maintain healthy iron absorption, avoid deficiencies and reduce cancer related ferritin levels.	During oncology doses of up to 3g to 9g daily, even higher, have been used with significant side effects	LINK
Selenium	Breast, Lung, Kidney, Ovarian, Cervical, Endometrial, Pancreatic, Melanoma, Head and Neck	Supplements are 200ug doses and similar amounts from about 3 brazil nuts. Start buildin gup your levels immediately and keep them high during oncology. Selenium toxicity is a consideration for high doses over time, so seek medical advice. Ideally taken with meals.	This trial used 2500 to 4000ug 2x daily for 14 days then once daily in kidney cancer with no dose limiting toxicity	LINK
Vitamin B3	Liver, Gastric, Glioblastoma, Non Hodgkin, Lymphoma, Leukemia, Non Melanoma Skin	Typically 500mg for nicotinamide (niacinamide) form of B3 taken ideally with meals	Do not differ from standard doses, here 500mg twice daily related to skin cancer	LINK
Akkermansia	Breast, TNBC, Prostate, Lung, Kidney, Liver, Ovarian, Cervical, Pancreatic, Non Hodgkin, Lymphoma, Leukemia, Myeloma, Head and Neck, Gastric	Commercial products may be at 10B CFU typically 30 minutes before or 2 hours after food. Ramp up levels with diet and moderate supplementation before treatments, especially immunotherapy.	Under development. Results in oncology indicate this is one of many helpful guy bacteria. careful consideration and particularly following use of antibiotics. Diversity is crucial.	LINK
Berberine	Kidney, Liver, Cervical, Pancreatic, Non Hodgkin, Leukemia, Myeloma, Head and Neck, Esophageal, Gallbladder, Thyroid, Non Melanoma Skin, Melanoma, Bladder	A natural anti-diabetic used frequently at 400mg daily and above, shortly before meals	In metabolic health trials frequentlu use up to 500mg at 3 times daily .	LINK
Curcumin	Colorectal, Liver, Non Hodgkin, Myeloma, Bladder, Gallbladder, Non Melanoma Skin, TNBC, Breast, Prostate, Lung, Kidney, Gastric, Ovarian, Cervical, Endometrial, Glioblastoma, Melanoma, Lymphoma, Leukemia, Head and Neck, Thyroid	Doses from 500mg to 2000mg frequently seen. Piperine fron black pepper improves absorption, highly bioavailable formulae are available. Ideally with a meal containing fat.	Higher doses in trials are frequently 2 of 4 g daily (+40 mg piperine) during oncology for instance here at 3 periods of 30 days	LINK
Quercetin	Glioblastoma, Myeloma	Can be found in a healty diet. Supplements often 500 or 1000mg and can be taken with tocotrienols for enhanced absorption, a form of vitamin E . Some evidence that Quercetin should be pulsed on/off.	Clincial trials have safely used up to 5g daily in adults, and 1 to 4g for rare forms of paediatric anemia	LINK
Urolithin A	Prostate, Lung, Colorectal, Kidney, Gastric, Glioblastoma, Melanoma, Myeloma, Gallbladder, Head and Neck	Typical commercial brands run at 500mg once or twice daily, with or without food, some brands suggest with meals	Trials eg in anti-aging science use the same dose range	LINK
Oat and Egg Functional Food	Breast, TNBC, Prostate, Lung, Colorectal, Kidney, Liver, Cervical, Pancreatic, Glioblastoma, Melanoma, Head and Neck, Gallbladder	Follow supplier guidance on dosage and use. https://shop.lantmannenfunctionalfoods.com/? Lowering tumor fluid pressure helps treatments work, start these before your treatment if possible. Use egg based salovum for short term "pulse" during therapy and oat products for sustained use over longer time periods	This trial in glioblastoma used 16g egg based Salovum four times daily. It discusses lowering that regime in follow on trials.	LINK
Coffee	Breast, Prostate, Colorectal, Liver, Non Melanoma Skin	Most dietary studies use standard 8oz servings as a guide. In many cases the findings are that benfits increase with intake. But in some cases such as prostate cancer there are important details in the PATHFINDER	No, but chlorogenic acid and, separately, green coffee extracts are used at 400mg and up to 2000mg
Flax	TNBC, Ovarian	Crushed flaxseed alone or in foods around 1/4 cup daily	Doses up to 50g daily in clinical trials for various diseases. Here a fairly typical 30g regime in inflammatory liver diseases	LINK
Propolis	Breast	Typical supplements range from 400 to 1000mg	Here 400mg x3 daily help recovery from radiotherapy	LINK
Walnuts	Prostate, Colorectal, Melanoma, Head and Neck	Dietary food item shown even at low useage to be helpful even at a few oz per week	Here, 2oz (56g) daily showed measurable activity in breast cancer	LINK
Mushroom	Prostate	Both dietary sources and many commercial supplements normally taken with food	In this example some patients saw responses between 8 and 14g daily of button mushroom extract	LINK
Zinc	Kidney, Ovarian, Cervical, Endometrial, Head and Neck, Non Melanoma Skin	Commercial supplements vary considerably . Moderate 20mg range generally advised	No
Intravenous HIgh Dose Vitamin C	Pancreatic, Glioblastoma	Commercial supplements vary. A moderate range around 20mg with food is generally accepted as safe.	Same as general guidance
Alpha Ketoglutarate	Melanoma, Kidney, TNBC, Non Hodgkin, Lymphoma	Typical usage is 1000mg daily with or without food, safety is good. Its especially important to ramp up and sustain your levels for maximum immunotherapy responses.	Larger doses of several grams have been safely used in various trials including here in bone disease at 6g daily	LINK
Horse Chestnut (Escin)	Thyroid	Common 300 to 600mg supplements contain 50 to 120mg of active compound, escin taken with food	Escin up to 150mg daily in vascular health. In oncology 0.6 mg/kg/day for 9 days, intravenous injection has been used, high absorption premium supplement would reacj this level	LINK

Treatments of surgery plus radio and/or chemotherapy are typically recommended first line treatment. With advancing disease some targeted drugs can be added, but real world studies do not shown reductions in overall risk https://pmc.ncbi.nlm.nih.gov/articles/PMC8165028/ In some specific cases other targeted drugs or immunotherapy may be added, and can get significant responses.

Your PATHFINDER brings together research that may help maximize the effects of radio and chemotherapy, helping reduce the risk of metastatic spread. The IMPACTS tab summarizes these and can lead to Many more Good days by helping treatments work, reducing your risk for progression and by easing treatment side effects. If you do elect both chemotherapy and targeted drugs, you can continue to look for ways to increase the results and reduce possible toxicities;

Be sure to fully read and absorb the PATHFINDER and its Impacts summary
If you have metastatic sites take a look into the corresponding Pathfinder for those too, for inspiration.
Use the Supplement Library Index and filter on “Chemotherapy” and “Targeted drugs” for ideas.
The Foods Library can complement your plan, including anti-metastatic strategies and metabolic health
In the Lifestyle section gathers fascinating evidence for diets and exercise
The PLANS section may have information from what others are doing and have learned

Endometrial

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