Evidence And Analysis Of Supplements For Fighting Cancer

SYSTEMIC

SUPPORTIVE

SYNERGISTIC

BROWSE LIBRARY ENTRIES

Browse our library of research often reporting remarkable impacts for supplements and non-precription compounds.

Lowering progression risks and reducing many of the debilitating side effects from oncology therapy.

Highest RATINGS are listed first.

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Library Principles

SUPPORT ONCOLOGY

Breakdown cancers resistance to oncology drugs helping them do their job more fully and effectively.

Minimize cancers ability to evade the full effects of your treatment

ENERGIZE NATURAL IMMUNITY

Find supplements that re-awaken and active your innate immune system.

Continually counteract cancers ability to mutate and spread after treatment

DETOX AND REBALANCE

Re-balance crucial levels of mineral and vitamins dysregulated by cancer progression.

Correct deficiencies, detoxify and help your treatment

RESTORE METABOLISM

Cancer switches many metabolic reactions to increase its own progression.

Actions of many compounds here can help rebalance these dysfunctions

CLICK the image to view the full library entry

ABOUT RATINGS

ANTIHISTAMINES

While we propose desloratadine and loratadine as novel anti-cancer drugs, they are not novel drugs, and are routinely given to cancer patients and others ..with few or no adverse effects.

Case records in many cancer types show lower progression risks
H1 classed Desloratadine and loratadine have the broadest evidence
Higher immunotherapy responses including melanoma and lung cancer

ASPIRIN

Meta-analyses of 118 observational studies of mortality in cancer patients give evidence consistent with reductions of about 20% in mortality associated with aspirin use

Substantial risk reductions often reported from large scale analysis of case records
Good evidence that aspirin can reduce metastasis, recurrence and all cause risk
Increasing reports that aspirin improves response rates to immunotherapies

ASTRAGALUS

We found a large treatment effect of adding astragalus-based herbal treatment to standard chemotherapy regimens. There is a pressing need for validation of these ﬁndings…

Studies of national patient prescription registers consistently report lowered progression risks
Recent trials within oncology beyond asia in advanced lung cancers are very compelling
Many actions in reduced side effects, from chemotherapy to improved immune system recover...

BETA GLUCANS

With more than 80 clinical trials evaluating their biological effects, the question is not if glucans will move from food supplement to widely accepted drug, but how soon.

Balances and energize the immune system, reduces resistance to treatment
Protective, reducing overall risk by limiting risks and side effects of drugs
Multiple commercial products in clinical trial phase, many high quality supplements

DANSHEN

After 10 years, survival rate analysis demonstrated a strong association between the use of danshen and survival

Analysis across multiple trials find reduced progression risks with chemotherapy
Evidence includes breast, prostate, lung, colorectal and bladder cancers
Reduce both side effects and all cause risk, including cardiovascular health

GREEN COFFEE EXTRACT

Among patients with advanced or metastatic colorectal cancer, this study found increased coffee intake to be associated with lower risk of disease progression

Coffee shown to reduce progression risk in multiple studies of patient records
Positive findings include colorectal, liver, gliomas (brain), prostate and most breast cancers
Green coffee extracts can deliver substantial doses of active compounds beyond caffeine

RED YEAST RICE

Among women with stage I-III TNBC incident statin use in the 12 months following breast cancer diagnosis was associated with an OS and BCSS benefit. Statins may have a role in select patients with breast cancer

Increasing evidence for benefits of statins during and after treatment across many cancer types
Frequently, effects are significant in “responders” where LDL is lowered on their introduction
Where a prescription statin is unavailable, red yeast rice is a natura...

TURKEYTAIL MUSHROOM

..we clearly showed an overall survival benefit (6.49 vs 3.59 years) in all patients with gastric cancer using PSK [turkey tail extract] in combination with chemotherapy

Much lower progression for sub groups in gastric, lung, breast and colorectal cancers
Patient immune system balancing and activation actions are shown in clinical results
Mushrooms and mushroom extracts can boost microbiome function and more

VITAMIN D3

Our findings suggest that there is a highly significant linear dose-response relationship between circulating 25-OH-D levels and overall survival in patients with breast cancer.

Large scale evidence in many cancers linking vitamin D3 levels to improved outcomes
Strongest effects in older male patients, especially colorectal and prostate cancers
Brand new research show significantly improved outcomes in immunotherapy with higher D3

LACTOFERRIN

We also observed a substantial decrease in the growth rate of target lesions before and after start of rhLF [lactoferrin]

Strong natural iron metabolism is a crucial success factor in targeted therapy
The vast majority of patients are deficient during treatment unless addressed
Direct in slowing progress of lung and renal cancers in some patients reported

MELATONIN

..MLT may benefit cancer patients who are also receiving chemotherapy, radiotherapy, supportive therapy, or palliative therapy by improving survival and ameliorating the side effects

Trials frequently report sustantially lowered progression at moderate/ high doses
Recent study in advanced lung cancer also shows reduced progression risks
Meta-analysis reports consistently reduced side effects particularly in advanced stages

CITRUS PECTIN

… durable benefit after 12 more months of therapy in this cohort, with 85% of patients having a durable long-term response, 62% a decreased/stable PSA

Effective results seen slowing prostate cancer progress usually PectaSol brand
Small but fascinating trial outcomes in other cancers often late stage relapsed cases
Heavy metal chelator able to reduce crucial metals such as lead, mercury and copper

SODIUM

Remarkably, serum sodium levels outperform the predictive power of PD-L1 status, the only widely used biomarker for immunotherapy response in the field of uro-oncology

Higher salt levels radically improve immunotherapy results
Almost all responders had higher sodium, while treatment depletes levels for most patients
Strong benefit in advanced kidney, bladder cancer and most solid tumors

ZINC

Our study provides preliminary evidence that there is a correlation between serum zinc levels and the efficacy of immunotherapy

New research links higher zinc levels to doubled immunotherapy response
Higher pre-diagnosis levels reduce progression risks in many cancers
Suggestions that supplements be combined with copper reduction

FERMENTED WHEATGERM

Continuous supplementation of anticancer therapies with MSC for more than 6 months is beneficial to patients with colorectal cancer in terms of overall and progression-free survival.

Small Phase II trials with good results in colorectal cancer and melanoma
Evidence so far only from branded products, requiring further validation
Lab studies show immunomodulatory actions.

INOSINE

Compared with the non-inosine group, the median PFS and ORR of the inosine group were significantly prolonged and improved in the multiple exploratory subgroup analyses.

Recent clinical study reports improved immunotherapy responses
Lung cancer outcomes in particular are improved with inosine supplementation
Immunotherapy outcomes in kidney cancer also improved with higher inosine

IODINE

Our data indicate that supplementation with I₂ improves the effectiveness of the treatment, decreasing side effects and increasing disease-free survival specially in advanced conditions

Molecular I₂ form substantially reduces post surgery progression rates and improves side effects
In high risk groups, adding I₂ to pre-emptive surgery give similar benefits
Readily available supplement in solution form, and start...

LUTEOLIN

..daily treatment with 50 mg of an oral supplement of luteolin is safe and effective with regard to oncological outcomes, particularly in (prostate cancer) patients under AS [active surveillance]

Recent evidence for slowing progression in early stage prostate cancer at 50mg dose levels
Indirect evidence for reducing rates of metastatic activity in digestive tract cancers
Anti-inflammatory actions may be increased combined with other compounds

SELENIUM

SLM [L-selenomethionine] (4000 μg) in sequential combination with axitinib is well tolerated with encouraging efficacy [kidney cancer].

Higher levels before and during treatment reported as slowing progression rates
Also evidence that oncology therapy results themselves benefit from selenium
Post-diagnostic higher dose supplementation strategies emerging in relapsed kidney cancer

SOY ISOFLAVONES

Soy isoflavones were associated with a 26% reduced risk of recurrence, particularly among postmenopausal and estrogen receptor–positive survivors, with the greatest risk reduction at 60 mg/day

Compelling evidence from recent multi-national meta-analysis of breast cancer outcomes and diet
Particularly good statistical data for stage III-IV groups, ER+ and ER- types
Active ingredient equol shown slowing pre-cancer phase in prostate disease.

VITAMIN B3

The results of these phase II studies suggest nicotinamide is effective in reducing AKs [actinica keratosis] and shows promise for skin cancer chemoprevention

Evidence of reducing immune evasion in digestive system cancers and glioblastoma
Reduces progression risks in female non smoker lung cancer treatment
Improves outcomes in non melanoma skin cancers & keratosis supporting oncology

AKKERMANSIA

Akkermansia muciniphila predicts vigorous response to immunotherapy in non-small-cell lung cancer

A natural level increases treatment responses especially immunotherapy
Often linked to lower progression rates, especially when part of highly diverse microbiota
Dietary sources including functional foods are the best way to sustain over time

BERBERINE

..has abundantly shown its ability to modulate these pathways without limiting side-effects, could be a safe and valid alternative to conventional drugs in breast cancer prevention

Incidence and progression of many cancers is reported with insulin resistance
Has strong evidence in insulin resistance and fasting blood glucose levels
Also contributes to improved cholesterol, anti-inflammatory effects, microbiome health

CURCUMIN

..the combination of curcumin with FOLFOX chemotherapy represents a safe and tolerable treatment with potential to provide patient benefit

Suppresses crucial inflammation and hormonal drives of cancer, its main clear use
Clinical evidence is limited to pilot trials so far, larger trials are needed
A high absorption formula may increase its effects, also combinations

EGCG

EGCG, has proven benefits in the treatment of reproductive cancers, including ovarian, cervical, endometrial, vaginal, and vulvar cancers

Some studies find reduced progression in breast and prostate cancer
Recent meta-analysis shows clear preventative effect for breast cancer
Also for reducing pain and side effects of radiotherapy (esophageal)

NATTOKINASE

Combined supplementation showed an advantage in anti-coagulation activities from increased antithrombin concentration, and down-regulating COX-1 related vasoconstriction

Reduces clotting, platelet aggregation and adhesion
Strong synergies with red yeast rice (or statin)
Separate actions complementary to aspirin use

ALPHA KETOGLUTARATE

When combined with anti-PD-L1 drugs (α-PD-L1), they significantly inhibited tumor growth without causing obvious side effects during treatment

Relatively higher patient AKG levels mean doubled immunotherapy responses
Compelling pre-clinical data reports AKG is essential to immune system activation
Researched in anti-aging for its ability to improve mitochrondial health, widely available

HORSE CHESTNUT

Escin significantly reduced the serum levels of TSH, TgAb, Tg, and calcitonin

Escin substantially extends survival in advanced thyroid cancer trials
Evidence in systemic vascular health points to anti-metastatic activity
Promising pre-clinical evidence in ovarian cancer

GARCINIA CAMBOGIA

strongly suggests that targeting cancer metabolism may be a reasonable option in advanced disease.

Also known as hydroxycitrate, shows metabolic actions in cancer
Early case studies in advanced stage cancers showed signs of benefits
Further large scale clinical studies are needed

LIPOIC ACID

These very primary results suggest the lack of toxicity and the probable efficacy of metabolic treatment in chemoresistant advanced carcinoma

Pilot clincial trials and case study evidence from integrative care
Used with garcini cambogia / hydroxycitrate for metabolic therapy
Evidence of standalone anti-inflammatory and metabolic benefits

QUERCETIN

Our findings provide support for the likelihood that the beneficial effects of intermittent [TKI] + Quercetin on cellular senescence

Successful use with tyrosine kinase inhibitors in non cancer lung disease
Evidence of significant anti-inflammatory effects relevant to cancer
Some clinical evidence for reductions in insulin and glucose levels

UROLITHIN A

Levels of plasma acylcarnitines and C-reactive proteins are significantly lower with Urolithin A indicating higher mitochondrial efficiency and reduced inflammation

Emerging evidence in regulating mitochondrial dysfuntion
Suppressing acylcarnitines, elevated in many cancers
First phase II trials include prostate cancer

GYMNEMA SYLVESTRE

G. sylvestre administration in patients with IGT decreased 2-h OGTT and A1C, increasing insulin sensitivity. There were also improvements in anthropometric measures and the lipid profile.

Clinical evidence is mainly as a natural anti-diabetic
Good evidence on glucose and lipid management
Lacking direct evidence in cancer to date

HONOKIOL

Honokiol might be a new potential treatment option for patients with recurrent GBM

Promising pre-clinincal lab studies especially in breast cancer
Evidence from 1-2 small trials of benefits as an adjuvant treatment
In lab tests, enhances effects of TKI carbozantinib in kidney cancer

MILK THISTLE

This translates into a 2.6 fold increase in the PSA doubling time from 445 to 1150 days for the supplement and placebo periods

Limited clinical evidence in direct anti-cancer actions
Has shown benefits in managing some treatment side-effects
Helps reduce insulin resistance and inflammation

PROPOLIS

Supplementation of propolis with radiotherapy treatment offer a quite measurable protection against DNA damage caused by ionizing radiation

Protectiive effects shown during radiotherapy
Reducing chemo related oral inflammation
Anti-inflammatory and metabolic actions

SULFORAPHANE

broccoli soup affected gene expression in the prostate of men on active surveillance, consistent with a reduction in the risk of cancer progression

Evidence of significant anti-inflammatory action
Increases metabolic health markers for insulin and LDL
Generally shown to have protective, risk reduction effects for several cancers

ARTEMISININ

patients who have previously undergone radical prostatectomy, 2/5 (40%) had improved PSA kinetics after artemisinin therapy.

A handful of small trials have shown positive signs
Evidence from large scale later phase trials lacking
Huge amount of pre-clinical studies done

BAICALEIN

our study hereby supports the clinical efficacy of baicalin in reducing blood lipids and inflammation in patients

Limited clinical trials do show use as an anti-inflammatory agent
Branded products in arthritis and vascular disease emerging
In chinese herbal medicine the effects are in combinations

BOSWELLIA

Boswellia serrata inhibited breast cancer proliferation and was well-tolerated in a Phase Ia window of opportunity trial

Recent clinical trial as an adjuvant to surgery in breast cancer showed promising effect
A few studies show anti-inflammatory actions in managing arthritis
Remaining studies are mostly pre-clinical/ lab studies only

BROMELAIN

IMM-101 treatment alongside an anti-inflammatory agent, such as bromelain… is a regimen that should be considered for treating patients with prostate cancer

Emerging commercial treatments for skin cancer (BCC)
Used to help new types of immunotherapy in development
Has been used in helping manage oncology side effects

CARDAMOM

The results showed that cardamom significantly reduced the levels of inflammatory factors, including hs‐CRP [high-sensitivity c-reactive protein]

Reasonable evidence of relevant anti-inflammatory actions relevant to cancers
Moderates dehydroepiandrosterone, associated with breast cancer
Can decrease androstenedione linked with prostate cancer progression

CITRUS BERGAMOT

..extremely effective in supporting healthy blood lipid levels through the optimization of total cholesterol, LDL cholesterol, HDL cholesterol

Citrus bergamot shows its main actions in controlling cholesterol
Often combined with other extracts or with statins in trials
Does show relevant anti-inflammatory actions but more data needed

ELLAGIC ACID

..after 12 weeks of enhanced insulin sensitivity decreased insulin secretion and improved..blood pressure, fasting glucose, and triglycerides

In systemic inflammatory diseases shown to improve metabolic health
Insulin resistance, inflammation and other markers associated with cancer
One key compound in functional foods that improve microbiome

NIGELLA SATIVA

potential to improve different clinical outcomes, such as blood glucose, inflammatory markers, oxidative stress factors, serum lipids

Mixed results in effects on key biomarkers most related to cancer
Large variations in clinical evidence and quality of research
So far no direct clinical evidence in cancer prevention or progression

RESVERATROL

The observed decrease in circulating IGF-I and IGFBP-3 might contribute to cancer chemopreventive activity

Clinical trials are few and with limited results shown
Indications of preventative potential in breast cancer
Weight loss efficacy in certain patient groups

PIPERLONGUMINE

“PL is selectively toxic to cancer cells with high drug-likeness and permeability, it may be a promising anti-cancer agent “

Moderately good evidence in blood sugar and cholesterol health
Mixed results in effects on key biomarkers most related to cancer
So far no direct clinical evidence in cancer prevention or progression

PIPERINE

known to enhance the bioavailability of a number of therapeutic agents including natural products

Clinical studies – with curcumin – show improvements in glucose, cholesterols and inflammation
With vitamin D and curcumin, piperine helps regulate inflammatory markers in auto-immune disease
In metabolic and liver health, piperine shows evidence of benefit in ...

APIGENIN

Apigenin may be of particular relevance to gastrointestinal disorders including colorectal cancer

Currently a lack of clinical evidence to show effects related to cancer
Potent natural compound present in many foods, parsley in particular
Most probable benefits in digestive system due to low absorption

ASHWAGANDHA

Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life.

There is a lack of any meaningful clinical trial evidence
Metabolic and anti-inflammatory results are also sparse
Small trials show health effects in stress and anxiety managemen

BUTTERBUR

“These findings indicate the promising potential of PT [Butterbur] as a potent ETCC1 [mitcochontrial – complex] inhibitor to target the metabolic vulnerability of tumor cells.”

Butterbur and its active ingredient petasin are used in migraine management based on clinical evidence
Interesting ability to cross blood brain barrier and overall penetration, anti-inflammatory actions in allergies
Limited studies include recent evidence on re-regulatin...

D-MANNOSE

“We consider that the administration of mannose could be a simple, safe and selective therapy in the treatment of cancer, and could be applicable to multiple tumour types..”

D-Mannose is an anti-bactieral, anti-inflammatory ingredient in foods such as cranberrry
Pre-clinical evidence shows a credible mechanism to increase effects of chemotherapy
Evidence from clinical trials is needed to show its anti-cancer effects carry over.

EMODIN

“emodin, a potent inhibitor of EMT [key step in metastasis], could serve as a potential candidate for ovarian cancer therapy.”

Also known as chinese rhubarb, interchangeable with Aloe Emodin
Pre-clinical research shows metabolic effect in glucose and lipid control
Promising lab studies in several cancer types and against metastasis

PTEROSTILBENE

..evidence points to pterostilbene’s strong anti-inflammatory and anti-cancer capabilities

An active compound in berries, almonds and more
Some evidence on anti-inflammatory actions
Related to resveratrol but higher absorption

SOURSOP

Experts warn against using soursop to treat cancer. While limited, lab-based research suggests this fruit may help fight cancer, it hasn’t been studied in humans

No clinical evidence or trials of any kind to support its use for cancer
Only test tube or mouse model evidence against cancer cells
More evidence in human patients, in any disease, is needed